AIM: The aim of this study was to evaluate the usefulness of glutamate pyruvate transaminase (GPT) levels in the diagnosis of metabolic syndrome (MS) in obese Japanese children. METHODS: We examined 193 obese boys (mean age: 12.1 yrs; mean percent overweight [POW]: 53.9%) and 37 obese girls (mean age: 11.4 yrs; mean POW: 57.2%). Anthropometric measurements, blood pressure and levels of liver transaminases, serum lipids and lipoproteins, fasting blood glucose (FBG), serum insulin and adiponectin were measured. The subjects were divided into either an MS or a non-MS group according to the MS definition criteria for Japanese children. RESULTS: The level of GPT was significantly higher in the MS group in both genders. Correlation analysis revealed positive correlations between GPT and waist circumference, blood pressure, maximum preperitoneal fat thickness, serum insulin and homeostasis model assessment-insulin resistance (HOMA-R), but no correlation between GPT and FBG. ANOVA showed a significant difference in GPT levels between MS and non-MS subgroups, whereas there was no difference in FBG between the two groups. Receiver operating characteristic curves demonstrated that GPT was clearly superior to FBG as a diagnostic marker of MS. CONCLUSION: We conclude that an elevation in GPT in obese children most likely reflects insulin resistance and that GPT is superior to FBG as a marker of MS.
AIM: The aim of this study was to evaluate the usefulness of glutamate pyruvate transaminase (GPT) levels in the diagnosis of metabolic syndrome (MS) in obese Japanese children. METHODS: We examined 193 obeseboys (mean age: 12.1 yrs; mean percent overweight [POW]: 53.9%) and 37 obesegirls (mean age: 11.4 yrs; mean POW: 57.2%). Anthropometric measurements, blood pressure and levels of liver transaminases, serum lipids and lipoproteins, fasting blood glucose (FBG), serum insulin and adiponectin were measured. The subjects were divided into either an MS or a non-MS group according to the MS definition criteria for Japanese children. RESULTS: The level of GPT was significantly higher in the MS group in both genders. Correlation analysis revealed positive correlations between GPT and waist circumference, blood pressure, maximum preperitoneal fat thickness, serum insulin and homeostasis model assessment-insulin resistance (HOMA-R), but no correlation between GPT and FBG. ANOVA showed a significant difference in GPT levels between MS and non-MS subgroups, whereas there was no difference in FBG between the two groups. Receiver operating characteristic curves demonstrated that GPT was clearly superior to FBG as a diagnostic marker of MS. CONCLUSION: We conclude that an elevation in GPT in obesechildren most likely reflects insulin resistance and that GPT is superior to FBG as a marker of MS.
Authors: M P Bahíllo-Curieses; F Hermoso-López; M J Martínez-Sopena; P Cobreros-García; P García-Saseta; M Tríguez-García; J M Marugán-Miguelsanz Journal: Endocrine Date: 2011-10-01 Impact factor: 3.633
Authors: Yu-Chung Tsao; Wen-Cheng Li; Wei-Chung Yeh; Steve Wen-Neng Ueng; Sherry Yueh-Hsia Chiu; Jau-Yuan Chen Journal: Int J Environ Res Public Health Date: 2020-12-02 Impact factor: 3.390
Authors: Zofia Wicik; Anna Nowak; Joanna Jarosz-Popek; Marta Wolska; Ceren Eyileten; Jolanta M Siller-Matula; Dirk von Lewinski; Harald Sourij; Krzysztof J Filipiak; Marek Postuła Journal: Front Pharmacol Date: 2022-08-15 Impact factor: 5.988