BACKGROUND: Stromal cell-derived factor (SDF)-1 and CXCR4 form an important chemokine ligand/receptor pair. Recent studies suggest that CXCR4 is expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in gastric cancer tissue has not been fully elucidated. PATIENTS AND METHODS: SDF-1 and CXCR4 expression levels in gastric cancer specimens obtained from 124 patients were examined by immunohistochemistry. RESULTS: The staining intensity of CXCR4 and SDF-1 in cancer cells was significantly higher in intestinal-type than in diffuse-type gastric cancer. There was a significant correlation between the expression of CXCR4 and SDF-1 and liver metastasis and lymphatic metastasis in the intestinal-type cancer; however, this correlation was not found in the diffuse-type cancer. Furthermore, intestinal-type cancer cells that permeated the vascular or lymphatic channels as well as liver and lymph node metastases showed strong CXCR4 and SDF-1 staining. CONCLUSION: The overexpressed CXCR4 and SDF-1 in intestinal-type cancer cells may be therapeutic targets for preventing lymphatic and hematogenous metastasis.
BACKGROUND:Stromal cell-derived factor (SDF)-1 and CXCR4 form an important chemokine ligand/receptor pair. Recent studies suggest that CXCR4 is expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in gastric cancer tissue has not been fully elucidated. PATIENTS AND METHODS: SDF-1 and CXCR4 expression levels in gastric cancer specimens obtained from 124 patients were examined by immunohistochemistry. RESULTS: The staining intensity of CXCR4 and SDF-1 in cancer cells was significantly higher in intestinal-type than in diffuse-type gastric cancer. There was a significant correlation between the expression of CXCR4 and SDF-1 and liver metastasis and lymphatic metastasis in the intestinal-type cancer; however, this correlation was not found in the diffuse-type cancer. Furthermore, intestinal-type cancer cells that permeated the vascular or lymphatic channels as well as liver and lymph node metastases showed strong CXCR4 and SDF-1 staining. CONCLUSION: The overexpressed CXCR4 and SDF-1 in intestinal-type cancer cells may be therapeutic targets for preventing lymphatic and hematogenous metastasis.
Authors: Wataru Shibata; Hiroshi Ariyama; Christoph Benedikt Westphalen; Daniel L Worthley; Sureshkumar Muthupalani; Samuel Asfaha; Zinaida Dubeykovskaya; Michael Quante; James G Fox; Timothy C Wang Journal: Gut Date: 2012-02-23 Impact factor: 23.059
Authors: Hyo Jin Lee; Song Mei Huang; Ha Yon Kim; Yoon Suk Oh; Ji Young Hwang; Zhe Long Liang; Jeong Ki Min; Hwan Jung Yun; Ji Young Sul; Samyong Kim; Deog Yeon Jo; Jin Man Kim Journal: Exp Ther Med Date: 2011-03-16 Impact factor: 2.447
Authors: Diego M Castilla; Zhao-Jun Liu; Runxia Tian; Yan Li; Alan S Livingstone; Omaida C Velazquez Journal: Ann Surg Date: 2012-10 Impact factor: 12.969