BACKGROUND: A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms. An association with peripheral arterial disease (PAD) was also reported in a sample younger than 75 years, but this disappeared on removal of respondents with a myocardial infarction history, resulting in an odds ratio of 1.09 for PAD (P=0.075). We aimed at estimating the association of this variant with an Ankle-Brachial Index (ABI) and PAD in 3 older populations. METHODS AND RESULTS: We used data from the InCHIANTI, Baltimore Longitudinal Study of Aging, and Health, Aging, and Body Composition studies. In 2630 white individuals (mean age, 76.4 years), the C allele at rs1333049 was associated with lower mean ABI measures and with an increased prevalence of PAD. These associations remained after removal of baseline and incident myocardial infarction cases over a 6-year follow-up for both ABI (-0.017 ABI units; 95% CI, -0.03 to -0.01; P = 1.3 x 10(-4)) and PAD (per allele odds ratio, 1.29; 95% CI, 1.06 to 1.56; P = 0.012). These associations also remained after adjustment for known atherosclerosis risk factors, including diabetes mellitus, smoking, hypercholesterolemia, and hypertension. CONCLUSIONS: The C allele at rs1333049 is associated with an increased prevalence of PAD and lower mean ABI. This association was independent of the presence of diagnosed myocardial infarction and atherosclerotic risk factors in 3 older white populations.
BACKGROUND: A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms. An association with peripheral arterial disease (PAD) was also reported in a sample younger than 75 years, but this disappeared on removal of respondents with a myocardial infarction history, resulting in an odds ratio of 1.09 for PAD (P=0.075). We aimed at estimating the association of this variant with an Ankle-Brachial Index (ABI) and PAD in 3 older populations. METHODS AND RESULTS: We used data from the InCHIANTI, Baltimore Longitudinal Study of Aging, and Health, Aging, and Body Composition studies. In 2630 white individuals (mean age, 76.4 years), the C allele at rs1333049 was associated with lower mean ABI measures and with an increased prevalence of PAD. These associations remained after removal of baseline and incident myocardial infarction cases over a 6-year follow-up for both ABI (-0.017 ABI units; 95% CI, -0.03 to -0.01; P = 1.3 x 10(-4)) and PAD (per allele odds ratio, 1.29; 95% CI, 1.06 to 1.56; P = 0.012). These associations also remained after adjustment for known atherosclerosis risk factors, including diabetes mellitus, smoking, hypercholesterolemia, and hypertension. CONCLUSIONS: The C allele at rs1333049 is associated with an increased prevalence of PAD and lower mean ABI. This association was independent of the presence of diagnosed myocardial infarction and atherosclerotic risk factors in 3 older white populations.
Authors: Margaret Kennedy; Cam Solomon; Teri A Manolio; Michael H Criqui; Anne B Newman; Joseph F Polak; Gregory L Burke; Paul Enright; Mary Cushman Journal: Arch Intern Med Date: 2005-09-12
Authors: Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich Journal: Nat Genet Date: 2006-07-23 Impact factor: 38.330
Authors: Viktor Janzen; Randolf Forkert; Heather E Fleming; Yoriko Saito; Michael T Waring; David M Dombkowski; Tao Cheng; Ronald A DePinho; Norman E Sharpless; David T Scadden Journal: Nature Date: 2006-09-06 Impact factor: 49.962
Authors: Gian Paolo Fadini; Anna Coracina; Ilenia Baesso; Carlo Agostini; Antonio Tiengo; Angelo Avogaro; Saula Vigili de Kreutzenberg Journal: Stroke Date: 2006-07-27 Impact factor: 7.914
Authors: Janakiraman Krishnamurthy; Matthew R Ramsey; Keith L Ligon; Chad Torrice; Angela Koh; Susan Bonner-Weir; Norman E Sharpless Journal: Nature Date: 2006-09-06 Impact factor: 49.962
Authors: Anna V Molofsky; Shalom G Slutsky; Nancy M Joseph; Shenghui He; Ricardo Pardal; Janakiraman Krishnamurthy; Norman E Sharpless; Sean J Morrison Journal: Nature Date: 2006-09-06 Impact factor: 49.962
Authors: N Yiannakouris; M Katsoulis; V Dilis; L D Parnell; D Trichopoulos; J M Ordovas; A Trichopoulou Journal: Atherosclerosis Date: 2012-02-28 Impact factor: 5.162
Authors: Christina L Wassel; Claudia Lamina; Vijay Nambi; Stefan Coassin; Kenneth J Mukamal; Santhi K Ganesh; David R Jacobs; Nora Franceschini; George J Papanicolaou; Quince Gibson; Lisa R Yanek; Pim van der Harst; Jane F Ferguson; Dana C Crawford; Lindsay L Waite; Matthew A Allison; Michael H Criqui; Mary M McDermott; Reena Mehra; L Adrienne Cupples; Shih-Jen Hwang; Susan Redline; Robert C Kaplan; Gerardo Heiss; Jerome I Rotter; Eric Boerwinkle; Herman A Taylor; Luis H Eraso; Margot Haun; Mingyao Li; Christa Meisinger; Jeffrey R O'Connell; Alan R Shuldiner; Anne Tybjærg-Hansen; Ruth Frikke-Schmidt; Barbara Kollerits; Barbara Rantner; Benjamin Dieplinger; Marietta Stadler; Thomas Mueller; Meinhard Haltmayer; Peter Klein-Weigel; Monika Summerer; H-Erich Wichmann; Folkert W Asselbergs; Gerjan Navis; Irene Mateo Leach; Kristin Brown-Gentry; Robert Goodloe; Themistocles L Assimes; Diane M Becker; John P Cooke; Devin M Absher; Jeffrey W Olin; Braxton D Mitchell; Muredach P Reilly; Emile R Mohler; Kari E North; Alexander P Reiner; Florian Kronenberg; Joanne M Murabito Journal: Atherosclerosis Date: 2012-02-02 Impact factor: 5.162
Authors: Anne M Scruggs; Hailey B Koh; Priya Tripathi; Nicholas J Leeper; Eric S White; Steven K Huang Journal: Am J Respir Cell Mol Biol Date: 2018-08 Impact factor: 6.914
Authors: Kelly P Downing; Kevin T Nead; Yoko Kojima; Themistocles Assimes; Lars Maegdefessel; Thomas Quertermous; John P Cooke; Nicholas J Leeper Journal: Vasc Med Date: 2013-12-09 Impact factor: 3.239
Authors: Lili Zhang; Petra Buzkova; Christina L Wassel; Mary J Roman; Kari E North; Dana C Crawford; Jonathan Boston; Kristin D Brown-Gentry; Shelley A Cole; Ewa Deelman; Robert Goodloe; Sarah Wilson; Gerardo Heiss; Nancy S Jenny; Neal W Jorgensen; Tara C Matise; Bob E McClellan; Alejandro Q Nato; Marylyn D Ritchie; Nora Franceschini; W H Linda Kao Journal: Atherosclerosis Date: 2013-03-13 Impact factor: 5.162
Authors: Christin E Burd; William R Jeck; Yan Liu; Hanna K Sanoff; Zefeng Wang; Norman E Sharpless Journal: PLoS Genet Date: 2010-12-02 Impact factor: 5.917