| Literature DB >> 20030343 |
Kilian Huber1, Jörg Schemies, Urszula Uciechowska, Julia M Wagner, Tobias Rumpf, Felicitas Lewrick, Regine Süss, Wolfgang Sippl, Manfred Jung, Franz Bracher.
Abstract
Class III histone deacetylases (sirtuins) play pivotal roles in many cellular processes. They are linked to extended lifespan and to the pathogenesis of cancer and neuronal disorders. We present novel sirtuin inhibitors based on a 6,7-dichloro-2-oxindole scaffold with low micromolar activity. In vitro activity was rationalized by docking studies, and hyperacetylation of sirtuin targets could be demonstrated in cell culture.Entities:
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Year: 2010 PMID： 20030343 DOI： 10.1021/jm901055u
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446