| Literature DB >> 20029447 |
Javier E Irazoqui1, Jonathan M Urbach, Frederick M Ausubel.
Abstract
The genetically tractable model organism Caenorhabditis elegans was first used to model bacterial virulence in vivo a decade ago. Since then, great strides have been made in identifying the host response pathways that are involved in its defence against infection. Strikingly, C. elegans seems to detect, and respond to, infection without the involvement of its homologue of Toll-like receptors, in contrast to the well-established role for these proteins in innate immunity in mammals. What, therefore, do we know about host defence mechanisms in C. elegans and what can they tell us about innate immunity in higher organisms?Entities:
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Year: 2010 PMID： 20029447 PMCID： PMC2965059 DOI： 10.1038/nri2689
Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106