Literature DB >> 20029421

Integrins in cancer: biological implications and therapeutic opportunities.

Jay S Desgrosellier1, David A Cheresh.   

Abstract

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions crucial to the initiation, progression and metastasis of solid tumours. The importance of integrins in several cell types that affect tumour progression has made them an appealing target for cancer therapy. Integrin antagonists, including the alphavbeta3 and alphavbeta5 inhibitor cilengitide, have shown encouraging activity in Phase II clinical trials and cilengitide is currently being tested in a Phase III trial in patients with glioblastoma. These exciting clinical developments emphasize the need to identify how integrin antagonists influence the tumour and its microenvironment.

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Year:  2010        PMID： 20029421      PMCID： PMC4383089          DOI： 10.1038/nrc2748

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  195 in total

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Authors:  G E Davis
Journal:  Biochem Biophys Res Commun       Date:  1992-02-14       Impact factor: 3.575

2.  Potentiation of neuroblastoma metastasis by loss of caspase-8.

Authors:  Dwayne G Stupack; Tal Teitz; Matthew D Potter; David Mikolon; Peter J Houghton; Vincent J Kidd; Jill M Lahti; David A Cheresh
Journal:  Nature       Date:  2006-01-05       Impact factor: 49.962

3.  Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells.

Authors:  F G Giancotti; E Ruoslahti
Journal:  Cell       Date:  1990-03-09       Impact factor: 41.582

4.  Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.

Authors:  E Petitclerc; S Strömblad; T L von Schalscha; F Mitjans; J Piulats; A M Montgomery; D A Cheresh; P C Brooks
Journal:  Cancer Res       Date:  1999-06-01       Impact factor: 12.701

5.  Requirement of vascular integrin alpha v beta 3 for angiogenesis.

Authors:  P C Brooks; R A Clark; D A Cheresh
Journal:  Science       Date:  1994-04-22       Impact factor: 47.728

6.  Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging.

Authors:  Patrick M Winter; Shelton D Caruthers; Andrea Kassner; Thomas D Harris; Lori K Chinen; John S Allen; Elizabeth K Lacy; Huiying Zhang; J David Robertson; Samuel A Wickline; Gregory M Lanza
Journal:  Cancer Res       Date:  2003-09-15       Impact factor: 12.701

7.  Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function.

Authors:  Angelika Kren; Vanessa Baeriswyl; François Lehembre; Christoph Wunderlin; Karin Strittmatter; Helena Antoniadis; Reinhard Fässler; Ugo Cavallaro; Gerhard Christofori
Journal:  EMBO J       Date:  2007-05-31       Impact factor: 11.598

8.  Integrin beta4 signaling promotes tumor angiogenesis.

Authors:  Sotiris N Nikolopoulos; Pamela Blaikie; Toshiaki Yoshioka; Wenjun Guo; Filippo G Giancotti
Journal:  Cancer Cell       Date:  2004-11       Impact factor: 31.743

9.  Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells.

Authors:  Chang-Qi Zhu; Svetlana N Popova; Ewan R S Brown; Dalia Barsyte-Lovejoy; Roya Navab; Warren Shih; Ming Li; Ming Lu; Igor Jurisica; Linda Z Penn; Donald Gullberg; Ming-Sound Tsao
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-28       Impact factor: 11.205

10.  Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.

Authors:  Patrick T Caswell; May Chan; Andrew J Lindsay; Mary W McCaffrey; David Boettiger; Jim C Norman
Journal:  J Cell Biol       Date:  2008-10-06       Impact factor: 10.539
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  1276 in total

1.  Coadministration of a tumor-penetrating peptide improves the therapeutic efficacy of paclitaxel in a novel air-grown lung cancer 3D spheroid model.

Authors:  Sweta K Gupta; Elisa A Torrico Guzmán; Samantha A Meenach
Journal:  Int J Cancer       Date:  2017-08-18       Impact factor: 7.396

2.  Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours.

Authors:  Johanne Seguin; Céline Nicolazzi; Nathalie Mignet; Daniel Scherman; Guy G Chabot
Journal:  Tumour Biol       Date:  2012-06-07

3.  Metastasis as a therapeutic target in prostate cancer: a conceptual framework.

Authors:  Konstantin Stoletov; David Bond; Katie Hebron; Srijan Raha; Andries Zijlstra; John D Lewis
Journal:  Am J Clin Exp Urol       Date:  2014-04

4.  Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1.

Authors:  Eduardo Sanabria-Figueroa; Siobhan M Donnelly; Kevin C Foy; Meghan C Buss; Robert C Castellino; Elisavet Paplomata; Latonia Taliaferro-Smith; Pravin T P Kaumaya; Rita Nahta
Journal:  Mol Pharmacol       Date:  2014-11-12       Impact factor: 4.436

Review 5.  Pathway inhibition: emerging molecular targets for treating glioblastoma.

Authors:  Wolfgang Wick; Michael Weller; Markus Weiler; Tracy Batchelor; Alfred W K Yung; Michael Platten
Journal:  Neuro Oncol       Date:  2011-06       Impact factor: 12.300

Review 6.  The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma.

Authors:  Alphonse E Sirica
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2011-11-29       Impact factor: 46.802

7.  Recombinant disintegrin targets α(v) β(3) integrin and leads to mediator production.

Authors:  Lívia C A Ribeiro; Lívia C Massimino; Araceli C Durante; Aline Tansini; Ana C Urbaczek; Heloísa S Selistre-de-Araújo; Iracilda Z Carlos
Journal:  Cell Adh Migr       Date:  2013-01-01       Impact factor: 3.405

8.  The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.

Authors:  Hao Zhang; Yu-Chung Chang; Mark L Brennan; Jinhua Wu
Journal:  J Mol Cell Biol       Date:  2013-11-28       Impact factor: 6.216

9.  Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma.

Authors:  Tomoyo Okada; Ann Y Lee; Li-Xuan Qin; Narasimhan Agaram; Takahiro Mimae; Yawei Shen; Rachael O'Connor; Miguel A López-Lago; Amanda Craig; Martin L Miller; Phaedra Agius; Evan Molinelli; Nicholas D Socci; Aimee M Crago; Fumi Shima; Chris Sander; Samuel Singer
Journal:  Cancer Discov       Date:  2016-08-30       Impact factor: 39.397

10.  Genome-wide scan reveals signatures of selection related to pollution adaptation in non-model estuarine Atlantic killifish (Fundulus heteroclitus).

Authors:  J S Osterberg; K M Cammen; T F Schultz; B W Clark; R T Di Giulio
Journal:  Aquat Toxicol       Date:  2018-04-25       Impact factor: 4.964
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