D B Richardson1. 1. Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. david.richardson@unc.edu
Abstract
OBJECTIVE: To discuss the use of discrete time hazards models for the analysis of occupational and environmental cohort data. METHODS: Analytical data structures and regression methods for discrete time hazards models are described. This approach is illustrated via analyses of data from a study of mortality in a cohort of chemical workers exposed to dioxin. RESULTS AND CONCLUSIONS: Analyses employing a discrete time hazards model facilitate examination of observed and expected counts, the calculation of attributable fractions, and empirical description of the estimated hazard rates. In addition, this approach can be used to fit non-multiplicative models, such as the linear hazards ratio model (which has been employed in epidemiological analyses of a variety of environmental and occupational exposures).
OBJECTIVE: To discuss the use of discrete time hazards models for the analysis of occupational and environmental cohort data. METHODS: Analytical data structures and regression methods for discrete time hazards models are described. This approach is illustrated via analyses of data from a study of mortality in a cohort of chemical workers exposed to dioxin. RESULTS AND CONCLUSIONS: Analyses employing a discrete time hazards model facilitate examination of observed and expected counts, the calculation of attributable fractions, and empirical description of the estimated hazard rates. In addition, this approach can be used to fit non-multiplicative models, such as the linear hazards ratio model (which has been employed in epidemiological analyses of a variety of environmental and occupational exposures).
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Authors: Signe Hjuler Boudigaard; Zara Ann Stokholm; Jesper Medom Vestergaard; Mette Skovgaard Mohr; Klaus Søndergaard; Kjell Torén; Vivi Schlünssen; Henrik A Kolstad Journal: Occup Environ Med Date: 2019-12-17 Impact factor: 4.402
Authors: Anne Vested; Ioannis Basinas; Alex Burdorf; Grethe Elholm; Dick J J Heederik; Gitte H Jacobsen; Henrik A Kolstad; Hans Kromhout; Øyvind Omland; Torben Sigsgaard; Ane M Thulstrup; Gunnar Toft; Jesper M Vestergaard; Inge M Wouters; Vivi Schlünssen Journal: Occup Environ Med Date: 2018-12-31 Impact factor: 4.402
Authors: Yuzhi Xi; David B Richardson; Abhijit V Kshirsagar; Timothy J Wade; Jennifer E Flythe; Eric A Whitsel; Geoffrey C Peterson; Lauren H Wyatt; Ana G Rappold Journal: Environ Health Date: 2022-03-11 Impact factor: 5.984