Literature DB >> 20028425

The optimal mode of delivery for the haemophilia carrier expecting an affected infant is caesarean delivery.

A H James1, K Hoots.   

Abstract

While a majority of affected infants of haemophilia carriers who deliver vaginally do not suffer a head bleed, the outcome of labour cannot be predicted. A planned vaginal delivery puts a woman at risk of an abnormal labour and operative vaginal delivery, both of which predispose to intracranial haemorrhage. Furthermore, vaginal delivery does not eliminate the risk to the haemophilia carrier herself. Overall, maternal morbidity and mortality from planned vaginal delivery are not significantly different from those from planned caesarean delivery. Caesarean delivery is recommended or elected now in conditions other than haemophilia carriage, where the potential benefits are not nearly as great. Additionally, vaginal delivery of the haemophilia carrier poses medical/legal risks if the infant is born with cephalohaematoma or intracranial haemorrhage. Caesarean delivery allows for a planned, controlled delivery. Caesarean delivery reduces the risk of intracranial haemorrhage by an estimated 85% and the risk can be nearly eliminated by performing elective caesarean delivery before labour. Therefore, after a discussion of the maternal and foetal risks with planned vaginal delivery versus planned caesarean delivery, haemophilia carriers should be offered the option of an elective caesarean delivery.

Entities:  

Mesh:

Year:  2009        PMID: 20028425     DOI: 10.1111/j.1365-2516.2009.02142.x

Source DB:  PubMed          Journal:  Haemophilia        ISSN: 1351-8216            Impact factor:   4.287


  10 in total

1.  A survey of the management of newborns with severe hemophilia in Canada.

Authors:  Paul C Moorehead; Jamie Ray; Nicholas J Barrowman; Brigitte Lemyre; Robert Klaassen
Journal:  Paediatr Child Health       Date:  2013-04       Impact factor: 2.253

2.  Complications of haemophilia in babies (first two years of life): a report from the Centers for Disease Control and Prevention Universal Data Collection System.

Authors:  R Kulkarni; R J Presley; J M Lusher; A D Shapiro; J C Gill; M Manco-Johnson; M A Koerper; T C Abshire; D DiMichele; W K Hoots; P Mathew; D J Nugent; S Geraghty; B L Evatt; J M Soucie
Journal:  Haemophilia       Date:  2016-11-04       Impact factor: 4.287

Review 3.  Congenital and acquired bleeding disorders in pregnancy.

Authors:  Terry B Gernsheimer
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2016-12-02

Review 4.  Maternal and foetal outcomes following natural vaginal versus caesarean section (c-section) delivery in women with bleeding disorders and carriers.

Authors:  Laxminarayan Karanth; Adinegara Bl Abas
Journal:  Cochrane Database Syst Rev       Date:  2021-12-09

Review 5.  Update on inherited disorders of haemostasis and pregnancy.

Authors:  Orly Lavee; Giselle Kidson-Gerber
Journal:  Obstet Med       Date:  2016-01-20

6.  Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.

Authors:  Irina V Chadaeva; Petr M Ponomarenko; Dmitry A Rasskazov; Ekaterina B Sharypova; Elena V Kashina; Dmitry A Zhechev; Irina A Drachkova; Olga V Arkova; Ludmila K Savinkova; Mikhail P Ponomarenko; Nikolay A Kolchanov; Ludmila V Osadchuk; Alexandr V Osadchuk
Journal:  BMC Genomics       Date:  2018-02-09       Impact factor: 3.969

7.  Cerebral microbleeds in a neonatal rat model.

Authors:  Brianna C Theriault; Seung Kyoon Woo; Jason K Karimy; Kaspar Keledjian; Jesse A Stokum; Amrita Sarkar; Turhan Coksaygan; Svetlana Ivanova; Volodymyr Gerzanich; J Marc Simard
Journal:  PLoS One       Date:  2017-02-03       Impact factor: 3.240

8.  Mode of delivery in hemophilia: vaginal delivery and Cesarean section carry similar risks for intracranial hemorrhages and other major bleeds.

Authors:  Nadine G Andersson; Elizabeth A Chalmers; Gili Kenet; Rolf Ljung; Anne Mäkipernaa; Hervé Chambost
Journal:  Haematologica       Date:  2019-02-21       Impact factor: 9.941

Review 9.  Maternal and foetal outcomes following natural vaginal versus caesarean section (c-section) delivery in women with bleeding disorders and carriers.

Authors:  Laxminarayan Karanth; Sachchithanantham Kanagasabai; Adinegara Bl Abas
Journal:  Cochrane Database Syst Rev       Date:  2017-08-04

10.  Acute Life-Threatening Hemorrhage in Neonates With Severe Hemophilia A: A Report of 3 Cases.

Authors:  Alvaro Moreira; Hrishikesh Das
Journal:  J Investig Med High Impact Case Rep       Date:  2018-09-18
  10 in total

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