| Literature DB >> 20028395 |
Elaine S Coimbra1, Mauro V de Almeida, Celso O R Júnior, Aline F Taveira, Cristiane F da Costa, Ana C de Almeida, Elaine F C Reis, Adilson D da Silva.
Abstract
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.Entities:
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Year: 2009 PMID： 20028395 DOI： 10.1111/j.1747-0285.2009.00923.x
Source DB: PubMed Journal: Chem Biol Drug Des ISSN： 1747-0277 Impact factor: 2.817