Literature DB >> 20028120

Amine-induced Michael/Conia-ene cascade reaction: application to a formal synthesis of (+/-)-Clavukerin A.

Wei Li1, Xiaozu Liu, Xiongfei Zhou, Chi-Sing Lee.   

Abstract

An efficient and versatile amine-induced Michael/Conia-ene cascade cyclization reaction has been developed for establishing 6,6- and 5,7-bicyclic fused carbocycles with simple acyclic beta-ketoesters as the substrates in one-pot condition and this new cyclization method has been successfully utilized in a formal synthesis of (+/-)-Clavukerin A.

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Year:  2010        PMID： 20028120     DOI： 10.1021/ol902567e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Effect of protic additives in Cu-catalysed asymmetric Diels-Alder cycloadditions of doubly activated dienophiles: towards the synthesis of magellanine-type Lycopodium alkaloids.

Authors:  Vincent N G Lindsay; Rebecca A Murphy; Richmond Sarpong
Journal:  Chem Commun (Camb)       Date:  2017-09-14       Impact factor: 6.222

2.  A Ruthenium-Catalyzed Coupling of Alkynes with 1,3-Diketones.

Authors:  Megan K Pennington-Boggio; Brian L Conley; Travis J Williams
Journal:  J Organomet Chem       Date:  2012-05-25       Impact factor: 2.369

3.  A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy.

Authors:  Jae Youp Cheong; Young Ho Rhee
Journal:  Beilstein J Org Chem       Date:  2011-06-01       Impact factor: 2.883

Review 4.  Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites.

Authors:  Víctor Coca-Ruíz; Ivonne Suárez; Josefina Aleu; Isidro G Collado
Journal:  Plants (Basel)       Date:  2022-03-14
  4 in total

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