Literature DB >> 20028090

Practical one-pot two-step protocol for the microwave-assisted synthesis of highly functionalized rhodanine derivatives.

Marco Radi1, Lorenzo Botta, Gianni Casaluce, Martina Bernardini, Maurizio Botta.   

Abstract

A fast and efficient protocol for the generation of substituted 5-arylidene rhodanines in a sequential one-pot two-step process combining the "Holmberg method" and the Knoevenagel condensation under microwave-assisted conditions has been developed. The final compounds 11a-k have been obtained in high yield and purity after a simple precipitation from methanol, making this procedure facile, practical, and rapid to execute.

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Year:  2010        PMID: 20028090     DOI: 10.1021/cc9001789

Source DB:  PubMed          Journal:  J Comb Chem        ISSN: 1520-4766


  5 in total

1.  Three-component, one-flask synthesis of rhodanines (thiazolidinones).

Authors:  Alexander M Jacobine; Gary H Posner
Journal:  J Org Chem       Date:  2011-08-31       Impact factor: 4.354

2.  Thiazolidine-2,4-dione derivative exhibits antitumoral effect and reverts behavioral and metabolic changes in a model of glioblastoma.

Authors:  Alana de Vasconcelos; Larissa Ribeiro de Moura; Nathalia Stark Pedra; Natália Pontes Bona; Mayara Sandrielly Pereira Soares; Magno da Silva Marques; Ana Paula Horn; Luiza Spohr; Roselia Maria Spanevello; Francieli Moro Stefanello; Wilson Cunico
Journal:  Metab Brain Dis       Date:  2022-05-26       Impact factor: 3.655

3.  One-pot solvent-free three-component reaction between primary amines, carbon disulfide, and 5-alkylidene rhodanines: a convenient synthesis of asymmetric birhodanines.

Authors:  Farough Nasiri; Parisa Nazari
Journal:  Mol Divers       Date:  2018-03-15       Impact factor: 2.943

4.  Environmentally Friendly Approach to Knoevenagel Condensation of Rhodanine in Choline Chloride: Urea Deep Eutectic Solvent and QSAR Studies on Their Antioxidant Activity.

Authors:  Maja Molnar; Harshad Brahmbhatt; Vesna Rastija; Valentina Pavić; Mario Komar; Maja Karnaš; Jurislav Babić
Journal:  Molecules       Date:  2018-07-29       Impact factor: 4.411

Review 5.  5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

Authors:  Danylo Kaminskyy; Anna Kryshchyshyn; Roman Lesyk
Journal:  Eur J Med Chem       Date:  2017-09-20       Impact factor: 6.514

  5 in total

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