Literature DB >> 20027919

Trypanosoma cruzi, cancer and the Cold War.

Nikolai Krementsov1.   

Abstract

In the summer of 1946, the international community of cancer researchers was inspired by the announcement that two Soviet scientists, Nina Kliueva and Grigorii Roskin, had discovered anticancer properties in culture extracts made from the South American protozoan, Trypanosoma cruzi, and had produced a preparation--named after its discoverers KR--which showed clear therapeutic effects on cancer patients. Research teams from various countries enthusiastically pursued the promising new line of investigation. The story of the rise and fall of interest in the anticancer properties of T. cruzi in different countries suggests that during the second half of the twentieth century, the Cold War competition between the superpowers played an important role in shaping the research agendas of cancer studies.

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Year:  2009        PMID: 20027919     DOI: 10.1590/s0104-59702009000500005

Source DB:  PubMed          Journal:  Hist Cienc Saude Manguinhos        ISSN: 0104-5970


  4 in total

1.  On labels and issues: the lysenko controversy and the cold war.

Authors:  William Dejong-Lambert; Nikolai Krementsov
Journal:  J Hist Biol       Date:  2012       Impact factor: 1.326

2.  Trypanosoma cruzi as an effective cancer antigen delivery vector.

Authors:  Caroline Junqueira; Luara I Santos; Bruno Galvão-Filho; Santuza M Teixeira; Flávia G Rodrigues; Wanderson D DaRocha; Egler Chiari; Achim A Jungbluth; Gerd Ritter; Sacha Gnjatic; Lloyd J Old; Ricardo T Gazzinelli
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-23       Impact factor: 11.205

Review 3.  Parasite Infection, Carcinogenesis and Human Malignancy.

Authors:  Hoang van Tong; Paul J Brindley; Christian G Meyer; Thirumalaisamy P Velavan
Journal:  EBioMedicine       Date:  2016-12-02       Impact factor: 8.143

4.  The Recombinant Protein Based on Trypanosoma cruzi P21 Interacts With CXCR4 Receptor and Abrogates the Invasive Phenotype of Human Breast Cancer Cells.

Authors:  Bruna Cristina Borges; Isadora Akemi Uehara; Marlus Alves Dos Santos; Flávia Alves Martins; Fernanda Carvalho de Souza; Álvaro Ferreira Junior; Felipe Andrés Cordero da Luz; Mylla Spirandelli da Costa; Ana Flávia Oliveira Notário; Daiana Silva Lopes; Samuel Cota Teixeira; Thaise Lara Teixeira; Patrícia de Castilhos; Claudio Vieira da Silva; Marcelo José Barbosa Silva
Journal:  Front Cell Dev Biol       Date:  2020-10-19
  4 in total

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