Literature DB >> 20027671

Modern lipid-, carbohydrate-, and peptide-based delivery systems for peptide, vaccine, and gene products.

Pavla Simerska1, Peter M Moyle, Istvan Toth.   

Abstract

Research related to peptide, vaccine, and gene delivery has grown exponentially over the last decade. In this review, we discuss the development of delivery systems for peptides, gene and vaccine products. Special focus is given to different lipidation and glycosylation strategies to improve the metabolic stability and membrane permeability of therapeutics, and their targeting to specific sites. The synthetic methods for preparation of the systems are also described.
© 2009 Wiley Periodicals, Inc.

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Year:  2009        PMID： 20027671     DOI： 10.1002/med.20191

Source DB:  PubMed          Journal:  Med Res Rev        ISSN： 0198-6325            Impact factor:   12.944


  11 in total

Review 1.  An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology.

Authors:  Y He; D Chen; W Zheng
Journal:  Oncogene       Date:  2015-03-23       Impact factor: 9.867

2.  Design, synthesis and characterisation of mannosylated ovalbumin lipid core peptide self-adjuvanting vaccine delivery system.

Authors:  Pavla Simerska; Zyta Maria Ziora; Vincent Fagan; Daryn Goodwin; Farrah Edrous; Istvan Toth
Journal:  Drug Deliv Transl Res       Date:  2014-06       Impact factor: 4.617

3.  Stability, permeability and growth-inhibitory properties of gonadotropin-releasing hormone liposaccharides.

Authors:  Daryn Goodwin; Pegah Varamini; Pavla Simerska; Istvan Toth
Journal:  Pharm Res       Date:  2014-11-19       Impact factor: 4.200

4.  Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides.

Authors:  Shayli Varasteh Moradi; Waleed M Hussein; Pegah Varamini; Pavla Simerska; Istvan Toth
Journal:  Chem Sci       Date:  2016-01-29       Impact factor: 9.825

Review 5.  Recent Advances in the Development of Peptide Vaccines and Their Delivery Systems Against Group A Streptococcus.

Authors:  Armira Azuar; Wanli Jin; Saori Mukaida; Waleed M Hussein; Istvan Toth; Mariusz Skwarczynski
Journal:  Vaccines (Basel)       Date:  2019-07-01

Review 6.  Peptide Lipidation - A Synthetic Strategy to Afford Peptide Based Therapeutics.

Authors:  Renata Kowalczyk; Paul W R Harris; Geoffrey M Williams; Sung-Hyun Yang; Margaret A Brimble
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622

Review 7.  Glycopeptide drugs: A pharmacological dimension between "Small Molecules" and "Biologics".

Authors:  Christopher R Apostol; Meredith Hay; Robin Polt
Journal:  Peptides       Date:  2020-07-13       Impact factor: 3.750

8.  A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation.

Authors:  Michelle P Christie; Pavla Simerská; Freda E-C Jen; Waleed M Hussein; Mohamad F M Rawi; Lauren E Hartley-Tassell; Christopher J Day; Michael P Jennings; Istvan Toth
Journal:  PLoS One       Date:  2014-04-15       Impact factor: 3.240

9.  Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold.

Authors:  Vincent Fagan; Istvan Toth; Pavla Simerska
Journal:  Beilstein J Org Chem       Date:  2014-07-30       Impact factor: 2.883

Review 10.  Chemical methods for peptide and protein production.

Authors:  Saranya Chandrudu; Pavla Simerska; Istvan Toth
Journal:  Molecules       Date:  2013-04-12       Impact factor: 4.411
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