PURPOSE: To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol. MATERIALS AND METHODS: A total of 20 patients with carotid stenosis >15% identified by duplex ultrasound were recruited for two independent 3T MRI (Philips) scans within one month. A multicontrast protocol including five MR sequences was applied: TOF, T1-/T2-/PD-weighted and magnetization-prepared rapid acquisition gradient-echo (MP-RAGE). Carotid artery morphology (wall volume, lumen volume, total vessel volume, normalized wall index, and mean/maximum wall thickness) and plaque component size (lipid rich/necrotic core, calcification, and hemorrhage) were measured over two time points. RESULTS: After exclusion of images with poor image quality, 257 matched locations from 18 subjects were available for analysis. For the quantitative carotid morphology measurements, coefficient of variation (CV) ranged from 2% to 15% and intraclass correlation coefficient (ICC) ranged from 0.87 to 0.99. Except for maximum wall thickness (ICC = 0.87), all ICC were larger than 0.90. For the quantitative plaque composition measurements, the ICC of the volume and relative content of lipid rich/necrotic core and calcification were larger than 0.90 with CV ranging from 22% to 32%. CONCLUSION: The results from the multicontrast high-resolution 3T MR study show high reliability for carotid morphology and plaque component measurements. 3T MRI is a reliable tool for longitudinal clinical trials, with shorter scan time compared to 1.5T. (c) 2009 Wiley-Liss, Inc.
PURPOSE: To evaluate interscan reproducibility of both vessel morphology and tissue composition measurements of carotid atherosclerosis using a fast, optimized, 3T multicontrast protocol. MATERIALS AND METHODS: A total of 20 patients with carotid stenosis >15% identified by duplex ultrasound were recruited for two independent 3T MRI (Philips) scans within one month. A multicontrast protocol including five MR sequences was applied: TOF, T1-/T2-/PD-weighted and magnetization-prepared rapid acquisition gradient-echo (MP-RAGE). Carotid artery morphology (wall volume, lumen volume, total vessel volume, normalized wall index, and mean/maximum wall thickness) and plaque component size (lipid rich/necrotic core, calcification, and hemorrhage) were measured over two time points. RESULTS: After exclusion of images with poor image quality, 257 matched locations from 18 subjects were available for analysis. For the quantitative carotid morphology measurements, coefficient of variation (CV) ranged from 2% to 15% and intraclass correlation coefficient (ICC) ranged from 0.87 to 0.99. Except for maximum wall thickness (ICC = 0.87), all ICC were larger than 0.90. For the quantitative plaque composition measurements, the ICC of the volume and relative content of lipid rich/necrotic core and calcification were larger than 0.90 with CV ranging from 22% to 32%. CONCLUSION: The results from the multicontrast high-resolution 3T MR study show high reliability for carotid morphology and plaque component measurements. 3T MRI is a reliable tool for longitudinal clinical trials, with shorter scan time compared to 1.5T. (c) 2009 Wiley-Liss, Inc.
Authors: R Kannan Mutharasan; C Shad Thaxton; Jarett Berry; Martha L Daviglus; Chun Yuan; Jie Sun; Colby Ayers; Donald M Lloyd-Jones; John T Wilkins Journal: J Lipid Res Date: 2017-01-03 Impact factor: 5.922
Authors: Jie Sun; Xue-Qiao Zhao; Niranjan Balu; Moni B Neradilek; Daniel A Isquith; Kiyofumi Yamada; Gádor Cantón; John R Crouse; Todd J Anderson; John Huston; Kevin O'Brien; Daniel S Hippe; Nayak L Polissar; Chun Yuan; Thomas S Hatsukami Journal: JACC Cardiovasc Imaging Date: 2017-03
Authors: Diederik F van Wijk; Aart C Strang; Raphael Duivenvoorden; Dirk-Jan F Enklaar; Rob J van der Geest; John J P Kastelein; Eric de Groot; Erik S G Stroes; Aart J Nederveen Journal: MAGMA Date: 2013-09-18 Impact factor: 2.310
Authors: Jie Sun; Yan Song; Huijun Chen; William S Kerwin; Daniel S Hippe; Li Dong; Min Chen; Cheng Zhou; Thomas S Hatsukami; Chun Yuan Journal: Stroke Date: 2013-03-07 Impact factor: 7.914