Literature DB >> 2002647

Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I.

J Haylor1, I Singh, A M el Nahas.   

Abstract

The effect of insulin-like growth factor I (IGF-I) on renal blood flow was measured in the anaesthetized rat using an electromagnetic flow probe. Renal vasodilation induced by IGF-I (50 micrograms/kg) was completely inhibited by NG-nitro-l-arginine methyl ester (50 mg/kg), an inhibitor of nitric oxide biosynthesis, but only partially reduced by indomethacin (10 mg/kg). The involvement of nitric oxide synthesis in the renal actions of IGF-I is proposed.

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Year:  1991        PMID： 2002647     DOI： 10.1038/ki.1991.42

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  20 in total

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