| Literature DB >> 20026177 |
Yasuo Miki1, Masahiko Tomiyama, Tatsuya Ueno, Rie Haga, Haruo Nishijima, Chieko Suzuki, Fumiaki Mori, Mitsuomi Kaimori, Masayuki Baba, Koichi Wakabayashi.
Abstract
To determine whether skin biopsy is practically useful in the premortem diagnosis for Parkinson's disease (PD), we examined Lewy pathology in the skin of the chest wall and leg, obtained from 6-mm punch biopsies, using phosphorylated alpha-synuclein antibody in 20 patients with clinically diagnosed PD. Abnormal accumulation of alpha-synuclein was found in the chest skin of two (10%) of 20 patients, but not in the leg. Although skin biopsy combined with a conventional immunohistochemistry for alpha-synuclein is not sufficient as a diagnostic tool, we could firstly demonstrate Lewy pathology in premortem tissue. The skin remains to be a promising tissue to be examined for the premortem diagnosis of PD. (c) 2009 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20026177 DOI： 10.1016/j.neulet.2009.12.027
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046