| Literature DB >> 20026149 |
TianDong Leng1, JingXia Zhang, Jun Xie, ShuJia Zhou, YiJun Huang, YueHan Zhou, WenBo Zhu, GuangMei Yan.
Abstract
Malignant gliomas are common and aggressive brain tumours in adults. The rapid proliferation and diffuse brain migration are the main obstacles to successful treatment. Here, we show 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol, a polyhydroxy steroid, is capable of suppressing proliferation and migration of C6 malignant glioma cells in a concentration-dependent manner. The compound 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol was synthesised by seven steps starting from diosgenin in 8.55% overall yield. The structures of the synthetic compounds were characterised by infrared (IR), (1)H nuclear magnetic resonance (NMR), (13)C NMR spectra and EA. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 20026149 DOI： 10.1016/j.steroids.2009.12.005
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668