Prediction of potential protein post-translational modifications of the thioredoxin-1 molecule.

Thioredoxin-1 is a 12-kDa protein with anti-oxidative, antiapoptotic and pro-proliferative functions, and it offers protection against cardiac hypertrophy. It has been found that the physiological regulation of thioredoxin-1 requires post-translational modifications and this may be an important step in the pathophysiology of cardiomyopathy. In this study, the potential protein post-translational modifications in thioredoxin-1 were determined with a standard bioinformatics technique, FindMod. No potential protein posttranslational modifications were found, which may indicate that they are not an important step in the pathophysiology of cardiomyopathy.