Literature DB >> 20024369

13C labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae.

Jien Wu1, Hai-Bao Zhang, Jin-Ling Xu, Russell J Cox, Thomas J Simpson, Lian-Hui Zhang.   

Abstract

The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with (13)C-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.

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Year:  2009        PMID： 20024369     DOI： 10.1039/b916307g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

Review 1.  Natural products from thioester reductase containing biosynthetic pathways.

Authors:  Michael W Mullowney; Ryan A McClure; Matthew T Robey; Neil L Kelleher; Regan J Thomson
Journal:  Nat Prod Rep       Date:  2018-09-19       Impact factor: 13.423

2.  Production of novel antibiotics zeamines through optimizing Dickeya zeae fermentation conditions.

Authors:  Lisheng Liao; Yingying Cheng; Shiyin Liu; Jianuan Zhou; Shuwen An; Mingfa Lv; Yufan Chen; Yanfang Gu; Shaohua Chen; Lian-Hui Zhang
Journal:  PLoS One       Date:  2014-12-26       Impact factor: 3.240

3.  Genetic Modulation of c-di-GMP Turnover Affects Multiple Virulence Traits and Bacterial Virulence in Rice Pathogen Dickeya zeae.

Authors:  Yufan Chen; Mingfa Lv; Lisheng Liao; Yanfang Gu; Zhibin Liang; Zurong Shi; Shiyin Liu; Jianuan Zhou; Lianhui Zhang
Journal:  PLoS One       Date:  2016-11-17       Impact factor: 3.240

4.  Fis is a global regulator critical for modulation of virulence factor production and pathogenicity of Dickeya zeae.

Authors:  Mingfa Lv; Yufan Chen; Lisheng Liao; Zhibin Liang; Zurong Shi; Yingxin Tang; Sixuan Ye; Jianuan Zhou; Lianhui Zhang
Journal:  Sci Rep       Date:  2018-01-10       Impact factor: 4.379

5.  A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics.

Authors:  Joleen Masschelein; Charlien Clauwers; Ufedo R Awodi; Karen Stalmans; Wesley Vermaelen; Eveline Lescrinier; Abram Aertsen; Chris Michiels; Gregory L Challis; Rob Lavigne
Journal:  Chem Sci       Date:  2014-10-15       Impact factor: 9.825

6.  A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics.

Authors:  Joleen Masschelein; Wesley Mattheus; Ling-Jie Gao; Pieter Moons; Rob Van Houdt; Birgit Uytterhoeven; Chris Lamberigts; Eveline Lescrinier; Jef Rozenski; Piet Herdewijn; Abram Aertsen; Chris Michiels; Rob Lavigne
Journal:  PLoS One       Date:  2013-01-17       Impact factor: 3.240

7.  The complete genome sequence of Dickeya zeae EC1 reveals substantial divergence from other Dickeya strains and species.

Authors:  Jianuan Zhou; Yingying Cheng; Mingfa Lv; Lisheng Liao; Yufan Chen; Yanfang Gu; Shiyin Liu; Zide Jiang; Yuanyan Xiong; Lianhui Zhang
Journal:  BMC Genomics       Date:  2015-08-04       Impact factor: 3.969

8.  Control of litchi downy blight by zeamines produced by Dickeya zeae.

Authors:  Lisheng Liao; Jianuan Zhou; Huishan Wang; Fei He; Shiyin Liu; Zide Jiang; Shaohua Chen; Lian-Hui Zhang
Journal:  Sci Rep       Date:  2015-10-26       Impact factor: 4.379

9.  Genome Sequence of the Banana Pathogen Dickeya zeae Strain MS1, Which Causes Bacterial Soft Rot.

Authors:  Jing-Xin Zhang; Bi-Run Lin; Hui-Fang Shen; Xiao-Ming Pu
Journal:  Genome Announc       Date:  2013-06-13

10.  The broad-spectrum antibiotic, zeamine, kills the nematode worm Caenorhabditis elegans.

Authors:  Josephine E E U Hellberg; Miguel A Matilla; George P C Salmond
Journal:  Front Microbiol       Date:  2015-02-26       Impact factor: 5.640
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