Literature DB >> 20024316

Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to alpha-ketoamides.

Yi-Xia Jia1, Dmitry Katayev, E Peter Kündig.   

Abstract

Pd/PtBu(3)-catalysed intramolecular nucleophilic addition of aryl halides to alpha-ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.

Entities:  

Year:  2009        PMID： 20024316     DOI： 10.1039/b917958e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Reductive Cyclization of Halo-Ketones to Form 3-Hydroxy-2-Oxindoles via Palladium Catalyzed Hydrogenation: A Hydrogen-Mediated Grignard Addition.

Authors:  Inji Shin; Stephen D Ramgren; Michael J Krische
Journal:  Tetrahedron       Date:  2015-09-02       Impact factor: 2.457

2.  Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source.

Authors:  Yuanyuan Xiao; Zijuan Yi; Xianyong Yu; Fang Xiao
Journal:  RSC Adv       Date:  2020-08-06       Impact factor: 4.036

3.  Stereoselective synthesis of tricyclic compounds by intramolecular palladium-catalyzed addition of aryl iodides to carbonyl groups.

Authors:  Jakub Saadi; Christoph Bentz; Kai Redies; Dieter Lentz; Reinhold Zimmer; Hans-Ulrich Reissig
Journal:  Beilstein J Org Chem       Date:  2016-06-16       Impact factor: 2.883
  3 in total

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