Literature DB >> 20024305

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition.

Marjoke F Debets1, Sander S van Berkel, Sanne Schoffelen, Floris P J T Rutjes, Jan C M van Hest, Floris L van Delft.   

Abstract

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

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Year:  2009        PMID： 20024305     DOI： 10.1039/b917797c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  128 in total

1.  Bioorthogonal reaction pairs enable simultaneous, selective, multi-target imaging.

Authors:  Mark R Karver; Ralph Weissleder; Scott A Hilderbrand
Journal:  Angew Chem Int Ed Engl       Date:  2011-12-12       Impact factor: 15.336

2.  Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells.

Authors:  Frédéric Friscourt; Petr A Ledin; Ngalle Eric Mbua; Heather R Flanagan-Steet; Margreet A Wolfert; Richard Steet; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2012-03-09       Impact factor: 15.419

3.  Preparation of unnatural N-to-N and C-to-C protein fusions.

Authors:  Martin D Witte; Juan J Cragnolini; Stephanie K Dougan; Nicholas C Yoder; Maximilian W Popp; Hidde L Ploegh
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-09       Impact factor: 11.205

Review 4.  Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications.

Authors:  Jeremiah A Johnson; Ying Y Lu; James A Van Deventer; David A Tirrell
Journal:  Curr Opin Chem Biol       Date:  2010-11-09       Impact factor: 8.822

5.  A Modular Method for the High-Yield Synthesis of Site-Specific Protein-Polymer Therapeutics.

Authors:  Yan Pang; Jinyao Liu; Yizhi Qi; Xinghai Li; Ashutosh Chilkoti
Journal:  Angew Chem Int Ed Engl       Date:  2016-07-21       Impact factor: 15.336

6.  Efficient Sortase-Mediated Ligation Using a Common C-Terminal Fusion Tag.

Authors:  Sierra A Reed; David A Brzovic; Savanna S Takasaki; Kristina V Boyko; John M Antos
Journal:  Bioconjug Chem       Date:  2020-04-23       Impact factor: 4.774

7.  A fluorogenic probe for the catalyst-free detection of azide-tagged molecules.

Authors:  Frédéric Friscourt; Christoph J Fahrni; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2012-11-02       Impact factor: 15.419

8.  3,6-Substituted-1,2,4,5-tetrazines: tuning reaction rates for staged labeling applications.

Authors:  Danzhu Wang; Weixuan Chen; Yueqin Zheng; Chaofeng Dai; Ke Wang; Bowen Ke; Binghe Wang
Journal:  Org Biomol Chem       Date:  2014-06-21       Impact factor: 3.876

9.  Facile Quenching and Spatial Patterning of Cylooctynes via Strain-Promoted Alkyne-Azide Cycloaddition of Inorganic Azides.

Authors:  Matthew Bjerknes; Hazel Cheng; Christopher D McNitt; Vladimir V Popik
Journal:  Bioconjug Chem       Date:  2017-05-09       Impact factor: 4.774

10.  Diazo Compounds as Highly Tunable Reactants in 1,3-Dipolar Cycloaddition Reactions with Cycloalkynes().

Authors:  Nicholas A McGrath; Ronald T Raines
Journal:  Chem Sci       Date:  2012-08-02       Impact factor: 9.825
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