Literature DB >> 20024286

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process.

Qian Cai1, Zhengqiu Li, Jiajia Wei, Chengyong Ha, Duanqing Pei, Ke Ding.   

Abstract

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-substrates under room temperature or mild conditions.

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Year:  2009        PMID： 20024286     DOI： 10.1039/b918345k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Molecular insights into Mmpl3 leads to the development of novel indole-2-carboxamides as antitubercular agents.

Authors:  Rajdeep Ray; Sumit Raosaheb Birangal; Fajeelath Fathima; Helena I Boshoff; He Eun Forbes; Raghu H Chandrashekhar; Gautham G Shenoy
Journal:  Mol Syst Des Eng       Date:  2022-03-02

2.  Indole synthesis: a review and proposed classification.

Authors:  Douglass F Taber; Pavan K Tirunahari
Journal:  Tetrahedron       Date:  2011-09-23       Impact factor: 2.457

3.  Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation.

Authors:  Suravi Chakrabarty; Shruti Choudhary; Arpit Doshi; Fa-Qiang Liu; Rishabh Mohan; Manasa P Ravindra; Dhruv Shah; Xun Yang; Fraser F Fleming
Journal:  Adv Synth Catal       Date:  2014-06-20       Impact factor: 5.837

4.  Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.

Authors:  Wandong Wen; Summer E Young; Matthew T Duvernay; Michael L Schulte; Kellie D Nance; Bruce J Melancon; Julie Engers; Charles W Locuson; Michael R Wood; J Scott Daniels; Wenjun Wu; Craig W Lindsley; Heidi E Hamm; Shaun R Stauffer
Journal:  Bioorg Med Chem Lett       Date:  2014-08-15       Impact factor: 2.823

5.  A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.

Authors:  Daigo Inoyama; Divya Awasthi; Glenn C Capodagli; Kholiswa Tsotetsi; Paridhi Sukheja; Matthew Zimmerman; Shao-Gang Li; Ravindra Jadhav; Riccardo Russo; Xin Wang; Courtney Grady; Todd Richmann; Riju Shrestha; Liping Li; Yong-Mo Ahn; Hsin Pin Ho Liang; Marizel Mina; Steven Park; David S Perlin; Nancy Connell; Véronique Dartois; David Alland; Matthew B Neiditch; Pradeep Kumar; Joel S Freundlich
Journal:  Cell Chem Biol       Date:  2020-03-19       Impact factor: 8.116
  5 in total

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