Literature DB >> 20024192

Analytical protocol for identification of BMAA and DAB in biological samples.

Zdenek Spácil1, Johan Eriksson, Sara Jonasson, Ulla Rasmussen, Leopold L Ilag, Birgitta Bergman.   

Abstract

Beta-N-methylamino-L-alanine (BMAA) is a non-protein amino acid, thought to be inflicting neurodegenerative diseases related to ALS/PDC in human beings. Due to conflicting data concerning the presence of BMAA in various biological matrixes, we present a robust and sensitive method for high confidence identification of BMAA after derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC). The efficient sample pretreatment in combination with LC-MS/MS SRM enables chromatographic separation of BMAA from the isomer 2,3-diaminobutyric acid (DAB). The method is applicable for selective BMAA/DAB detection in various biological samples ranging from a prokaryotic cyanobacterium to eukaryotic fish.

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Year:  2009        PMID： 20024192     DOI： 10.1039/b921048b

Source DB:  PubMed          Journal:  Analyst        ISSN： 0003-2654            Impact factor:   4.616


  23 in total

1.  Assessment of the non-protein amino acid BMAA in Mediterranean mussel Mytilus galloprovincialis after feeding with estuarine cyanobacteria.

Authors:  Mafalda S Baptista; Rita G W Vasconcelos; Paula C Ferreira; C Marisa R Almeida; Vitor M Vasconcelos
Journal:  Environ Sci Pollut Res Int       Date:  2015-04-24       Impact factor: 4.223

Review 2.  A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.

Authors:  N Chernoff; D J Hill; D L Diggs; B D Faison; B M Francis; J R Lang; M M Larue; T-T Le; K A Loftin; J N Lugo; J E Schmid; W M Winnik
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2017-06-09       Impact factor: 6.393

3.  Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure.

Authors:  Sara Jonasson; Johan Eriksson; Lotta Berntzon; Zdenek Spácil; Leopold L Ilag; Lars-Olof Ronnevi; Ulla Rasmussen; Birgitta Bergman
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-03       Impact factor: 11.205

Review 4.  Methods for the Chemical Analysis of β-N-Methylamino-L-A lanine: What Is Known and What Remains to Be Determined.

Authors:  Sandra Anne Banack; Susan J Murch
Journal:  Neurotox Res       Date:  2017-05-04       Impact factor: 3.911

5.  Prominent human health impacts from several marine microbes: history, ecology, and public health implications.

Authors:  P K Bienfang; S V Defelice; E A Laws; L E Brand; R R Bidigare; S Christensen; H Trapido-Rosenthal; T K Hemscheidt; D J McGillicuddy; D M Anderson; H M Solo-Gabriele; A B Boehm; L C Backer
Journal:  Int J Microbiol       Date:  2010-10-11

6.  BMAA extraction of cyanobacteria samples: which method to choose?

Authors:  Sandra Lage; Alfred Burian; Ulla Rasmussen; Pedro Reis Costa; Heléne Annadotter; Anna Godhe; Sara Rydberg
Journal:  Environ Sci Pollut Res Int       Date:  2015-08-26       Impact factor: 4.223

7.  Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? A Response to a Critical Review of the BMAA Hypothesis.

Authors:  Dunlop Ra; Banack Sa; Bishop Sl; Metcalf Js; Murch Sj; Davis DA; Stommel Ew; Karlsson O; Brittebo Eb; Chatziefthimiou Ad; Tan Vx; Guillemin Gg; Cox Pa; Mash Dc; Bradley Wg
Journal:  Neurotox Res       Date:  2021-02-06       Impact factor: 3.911

8.  Evaluation of a commercial enzyme linked immunosorbent assay (ELISA) for the determination of the neurotoxin BMAA in surface waters.

Authors:  Elisabeth J Faassen; Wendy Beekman; Miquel Lürling
Journal:  PLoS One       Date:  2013-06-07       Impact factor: 3.240

9.  A comparative study on three analytical methods for the determination of the neurotoxin BMAA in cyanobacteria.

Authors:  Elisabeth J Faassen; Frits Gillissen; Miquel Lürling
Journal:  PLoS One       Date:  2012-05-03       Impact factor: 3.240

Review 10.  Presence of the neurotoxin BMAA in aquatic ecosystems: what do we really know?

Authors:  Elisabeth J Faassen
Journal:  Toxins (Basel)       Date:  2014-03-21       Impact factor: 4.546
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