AIMS: The clinical course including the outcome of acute decompensated heart failure (ADHF) correlates with renal dysfunction, but the evaluation of renal function has not yet been standardized. We therefore investigated the relationship between the prognosis of ADHF and acute kidney injury (AKI) evaluated using the risk, injury, failure, loss, end stage (RIFLE) criteria. METHODS AND RESULTS: This study assessed 376 consecutive patients with ADHF admitted to the intensive care unit (ICU) (mean age 71.6 years; 238 male). The underlying aetiology was ischaemic heart disease, hypertensive heart disease, cardiomyopathy, valvular diseases, and 'other' in 124, 70, 60, 107, and 15 patients, respectively. We defined AKI according to the RIFLE criteria, and the most severe RIFLE classifications during hospitalization were adopted to assess patient outcomes. The in-hospital mortality was significantly higher among patients with AKI (29 of 275; 10.5%) than in those without AKI (1 of 101; 1.0%, P = 0.0010). Both ICU and hospital stays were longer for patients with AKI (8.8 +/- 15.4 vs. 48.6 +/- 47.6 days), than for patients without (5.0 +/- 2.8 vs. 25.7 +/- 16.8 days, P < 0.05 and P < 0.001). CONCLUSION: Acute kidney injury evaluated by the RIFLE criteria was associated with a poorer outcome for patients with ADHF.
AIMS: The clinical course including the outcome of acute decompensated heart failure (ADHF) correlates with renal dysfunction, but the evaluation of renal function has not yet been standardized. We therefore investigated the relationship between the prognosis of ADHF and acute kidney injury (AKI) evaluated using the risk, injury, failure, loss, end stage (RIFLE) criteria. METHODS AND RESULTS: This study assessed 376 consecutive patients with ADHF admitted to the intensive care unit (ICU) (mean age 71.6 years; 238 male). The underlying aetiology was ischaemic heart disease, hypertensive heart disease, cardiomyopathy, valvular diseases, and 'other' in 124, 70, 60, 107, and 15 patients, respectively. We defined AKI according to the RIFLE criteria, and the most severe RIFLE classifications during hospitalization were adopted to assess patient outcomes. The in-hospital mortality was significantly higher among patients with AKI (29 of 275; 10.5%) than in those without AKI (1 of 101; 1.0%, P = 0.0010). Both ICU and hospital stays were longer for patients with AKI (8.8 +/- 15.4 vs. 48.6 +/- 47.6 days), than for patients without (5.0 +/- 2.8 vs. 25.7 +/- 16.8 days, P < 0.05 and P < 0.001). CONCLUSION:Acute kidney injury evaluated by the RIFLE criteria was associated with a poorer outcome for patients with ADHF.
Authors: Andrew K Roy; Catherine Mc Gorrian; Cecelia Treacy; Edel Kavanaugh; Alice Brennan; Niall G Mahon; Patrick T Murray Journal: Cardiorenal Med Date: 2013-02-26 Impact factor: 2.041
Authors: Wim Vandenberghe; Sofie Gevaert; John A Kellum; Sean M Bagshaw; Harlinde Peperstraete; Ingrid Herck; Johan Decruyenaere; Eric A J Hoste Journal: Cardiorenal Med Date: 2015-12-19 Impact factor: 2.041
Authors: Justin L Grodin; Susanna R Stevens; Lisa de Las Fuentes; Michael Kiernan; Edo Y Birati; Divya Gupta; Bradley A Bart; G Michael Felker; Horng H Chen; Javed Butler; Victor G Dávila-Román; Kenneth B Margulies; Adrian F Hernandez; Kevin J Anstrom; W H Wilson Tang Journal: J Card Fail Date: 2015-07-21 Impact factor: 5.712
Authors: Filippo Brandimarte; Muthiah Vaduganathan; Gian Francesco Mureddu; Giuseppe Cacciatore; Hani N Sabbah; Gregg C Fonarow; Steven R Goldsmith; Javed Butler; Francesco Fedele; Mihai Gheorghiade Journal: Heart Fail Rev Date: 2013-03 Impact factor: 4.214