OBJECTIVE: CA-125 is an old marker, recently shown to be associated with systolic heart failure. We aimed to search for factors influencing its plasma level. DESIGN: 430 patients with one available CA-125 level were investigated retrospectively. 150 patients who had echocardiographic records were enrolled into final analysis. Patients were followed up, hospitalization and mortality were noted. RESULTS: CA-125 levels were negatively correlated with ejection fraction (r=-0.269, p=0.001) and positively correlated with systolic pulmonary artery pressure (r=0.370, p<0.001). In the whole group, patients with right ventricular dilatation (n=68) had significantly higher CA-125 levels compared to those without right ventricular dilatation (n=82) (125.8±118.4 U/ml vs.16.9±16.5 U/ml, p<0.001). Presence of depressed ejection fraction (B=1.837, p=0.004), presence of right ventricular dilatation (B=4.294, p=0.002) and presence of pericardial effusion (B=1.913, p=0.018) were independent predictors of high CA-125 levels. After follow up, patients with high CA-125 level encountered more frequent hospitalization and mortality, and atrial fibrillation was more frequent among those with high CA-125. CONCLUSION: Our data suggests that plasma levels of CA-125 seem to be determined by left ventricular ejection fraction, right ventricular dilatation and presence of pericardial effusion in a group of all comers. It seems prudent to consider these factors before integrating CA-125 into clinical practice.
OBJECTIVE:CA-125 is an old marker, recently shown to be associated with systolic heart failure. We aimed to search for factors influencing its plasma level. DESIGN: 430 patients with one available CA-125 level were investigated retrospectively. 150 patients who had echocardiographic records were enrolled into final analysis. Patients were followed up, hospitalization and mortality were noted. RESULTS:CA-125 levels were negatively correlated with ejection fraction (r=-0.269, p=0.001) and positively correlated with systolic pulmonary artery pressure (r=0.370, p<0.001). In the whole group, patients with right ventricular dilatation (n=68) had significantly higher CA-125 levels compared to those without right ventricular dilatation (n=82) (125.8±118.4 U/ml vs.16.9±16.5 U/ml, p<0.001). Presence of depressed ejection fraction (B=1.837, p=0.004), presence of right ventricular dilatation (B=4.294, p=0.002) and presence of pericardial effusion (B=1.913, p=0.018) were independent predictors of high CA-125 levels. After follow up, patients with high CA-125 level encountered more frequent hospitalization and mortality, and atrial fibrillation was more frequent among those with high CA-125. CONCLUSION: Our data suggests that plasma levels of CA-125 seem to be determined by left ventricular ejection fraction, right ventricular dilatation and presence of pericardial effusion in a group of all comers. It seems prudent to consider these factors before integrating CA-125 into clinical practice.
Authors: H Yucel; H Kaya; A Zorlu; K Yıldırımlı; E Sancakdar; H Gunes; R Kurt; U Ozgul; O O Turgut; M B Yilmaz Journal: Herz Date: 2014-09-27 Impact factor: 1.443
Authors: Angel Cheung; Mengqi Gong; Roberto Bellanti; Sadeq Ali-Hasan-Al-Saegh; Guangping Li; Eulàlia Roig; Julio Núñez; Thomas D Stamos; Mehmet Birhan Yilmaz; Kaya Hakki; William K K Wu; Sunny Hei Wong; Wing Tak Wong; George Bazoukis; Konstantinos Lampropoulos; Lah Ah Tse; Jichao Zhao; Gregory Y H Lip; Adrian Baranchuk; Martin C S Wong; Tong Liu; Gary Tse Journal: Heart Asia Date: 2018-01-07
Authors: Weronika Bulska-Będkowska; Elżbieta Chełmecka; Aleksander J Owczarek; Katarzyna Mizia-Stec; Andrzej Witek; Aleksandra Szybalska; Tomasz Grodzicki; Magdalena Olszanecka-Glinianowicz; Jerzy Chudek Journal: J Clin Med Date: 2019-05-03 Impact factor: 4.241