Literature DB >> 20022501

Synthesis of 4'-ester analogs of resveratrol and their evaluation in malignant melanoma and pancreatic cell lines.

Yong Wong1, Gregory Osmond, Kenneth I Brewer, Douglas S Tyler, Merritt B Andrus.   

Abstract

4'-Ester analogs of the disease preventative agent resveratrol were synthesized and evaluated for their potential as anti-melanoma and pancreatic cancer agents. A decarbonylative Heck coupling was used to assemble the protected stilbene core structure. The 4'-acetate and the palmitoate analogs demonstrated selective activity with DM443 and DM738 cells over normal NHDF cells. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 20022501     DOI： 10.1016/j.bmcl.2009.12.006

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells.

Authors:  Valery L Morris; Tayyaba Toseef; Fathima B Nazumudeen; Christian Rivoira; Carmela Spatafora; Corrado Tringali; Susan A Rotenberg
Journal:  Mol Cell Biochem       Date:  2015-01-08       Impact factor: 3.396

2.  Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications.

Authors:  Edwin D Lephart; Merritt B Andrus
Journal:  Exp Biol Med (Maywood)       Date:  2017-07-27

Review 3.  Botanicals for the prevention and treatment of cutaneous melanoma.

Authors:  Deeba N Syed; Hasan Mukhtar
Journal:  Pigment Cell Melanoma Res       Date:  2011-04-12       Impact factor: 4.693

Review 4.  The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges.

Authors:  Mary Ndiaye; Carol Philippe; Hasan Mukhtar; Nihal Ahmad
Journal:  Arch Biochem Biophys       Date:  2011-01-04       Impact factor: 4.013

5.  In vitro and in vivo evaluation of resveratrol and 3,5-dihydroxy-4'-acetoxy-trans-stilbene in the treatment of human prostate carcinoma and melanoma.

Authors:  Gregory W Osmond; Elizabeth M Masko; Douglas S Tyler; Stephen J Freedland; Salvatore Pizzo
Journal:  J Surg Res       Date:  2012-03-28       Impact factor: 2.192

6.  The Effects of 4'-Esterified Resveratrol Derivatives on Calcium Dynamics in Breast Cancer Cells.

Authors:  Joshua A Peterson; Hayden P Doughty; Austin J Eells; Trent A Johnson; Jordan P Hastings; Colton M Crowther; Merritt B Andrus; Jason D Kenealey
Journal:  Molecules       Date:  2017-11-14       Impact factor: 4.411
  6 in total

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