OBJECTIVE: Glucocorticoid administration to women in preterm labor improves neonatal mortality and morbidity. Fetal exposure to glucocorticoid levels higher than those appropriate to the current gestational stage has multiple organ system effects. Some, eg, fetal hypertension, are maximal at lower than the clinical dose. We hypothesized that the clinical dose has supramaximal lung maturational effects. STUDY DESIGN: We evaluated the full, half, and quarter clinical betamethasone dose (12 mg/70 kg or 170 microg/kg intramuscularly twice 24 hours apart) on fetal sheep lung pressure volume curves (PVC) after 48 hours' exposure at 0.75 gestation. We measured key messenger RNAs and protein products that affect lung function and total lung dipalmitoyl phosphatidyl choline. RESULTS: Full and half doses had similar PVC and total lung dipalmitoyl phosphatidyl choline effects. Messenger RNA for surfactant proteins A, B, and D and elastin increased in a dose-dependent fashion. CONCLUSION: Half the clinical betamethasone dose produces maximal PVC improvement in fetal sheep at 0.75 gestation. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: Glucocorticoid administration to women in preterm labor improves neonatal mortality and morbidity. Fetal exposure to glucocorticoid levels higher than those appropriate to the current gestational stage has multiple organ system effects. Some, eg, fetal hypertension, are maximal at lower than the clinical dose. We hypothesized that the clinical dose has supramaximal lung maturational effects. STUDY DESIGN: We evaluated the full, half, and quarter clinical betamethasone dose (12 mg/70 kg or 170 microg/kg intramuscularly twice 24 hours apart) on fetal sheep lung pressure volume curves (PVC) after 48 hours' exposure at 0.75 gestation. We measured key messenger RNAs and protein products that affect lung function and total lung dipalmitoyl phosphatidyl choline. RESULTS: Full and half doses had similar PVC and total lung dipalmitoyl phosphatidyl choline effects. Messenger RNA for surfactant proteins A, B, and D and elastin increased in a dose-dependent fashion. CONCLUSION: Half the clinical betamethasone dose produces maximal PVC improvement in fetal sheep at 0.75 gestation. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: Angela Chueh Chao; Bassem I Ziadeh; Guan-Yeu Diau; Vasuki Wijendran; Eszter Sarkadi-Nagy; Andrea T Hsieh; Peter W Nathanielsz; J Thomas Brenna Journal: Lipids Date: 2003-04 Impact factor: 1.880
Authors: Rosa Karemaker; Annemieke Kavelaars; Maike ter Wolbeek; Marijke Tersteeg-Kamperman; Wim Baerts; Sylvia Veen; Jannie F Samsom; Gerard H A Visser; Frank van Bel; Cobi J Heijnen Journal: Pediatrics Date: 2008-04 Impact factor: 7.124
Authors: Thomas Schmitz; Laura A Cox; Cun Li; Brian A Levine; Stephen P Ford; Thomas J McDonald; Peter W Nathanielsz Journal: Pediatr Res Date: 2007-04 Impact factor: 3.756
Authors: Tanzila Mahzabin; J Jane Pillow; Gavin J Pinniger; Anthony J Bakker; Peter B Noble; Robert B White; Kanakeswary Karisnan; Yong Song Journal: Pediatr Res Date: 2017-05-17 Impact factor: 3.756
Authors: Kurt H Albertine; Mar Janna Dahl; Linda W Gonzales; Zheng-Ming Wang; Drew Metcalfe; Dallas M Hyde; Charles G Plopper; Barry C Starcher; David P Carlton; Richard D Bland Journal: Am J Physiol Lung Cell Mol Physiol Date: 2010-04-09 Impact factor: 5.464
Authors: Jennifer J P Collins; Elke Kuypers; Ilias Nitsos; J Jane Pillow; Graeme R Polglase; Matthew W Kemp; John P Newnham; Jack P Cleutjens; Suzanna G M Frints; Suhas G Kallapur; Alan H Jobe; Boris W Kramer Journal: Am J Physiol Lung Cell Mol Physiol Date: 2012-09-07 Impact factor: 5.464
Authors: Marta Perez; Kamila Wisniewska; Keng Jin Lee; Herminio J Cardona; Joann M Taylor; Kathryn N Farrow Journal: Pediatr Res Date: 2016-01-12 Impact factor: 3.756