Literature DB >> 20022072

High-saturated-fat diet induces gestational diabetes and placental vasculopathy in C57BL/6 mice.

Chengya Liang1, Kristi DeCourcy, Mary R Prater.   

Abstract

Gestational diabetes mellitus (GDM) is a commonly encountered disorder of mid to late pregnancy that is characterized by hyperglycemia, hyperinsulinemia, and impaired glucose tolerance. Gestational diabetes mellitus is thought to be multifactorial in origin and derives from both genetic and environmental factors. However, the mechanisms underlying GDM are incompletely understood; and current GDM animal models do not appear to closely mimic the clinical situation in humans. The present study used environmental exposure to high-saturated-fat diet (HFD) in an effort to develop a GDM mouse model that closely simulates metabolic abnormalities seen in human GDM. This model was then used to determine the contributions of HFD-induced placental oxidative stress (OS) and vascular dysregulation, which are observed in GDM patients and are believed to contribute to the pathogenesis of the disease. Pathologic manifestations of the disease were quantified by evaluating the extent of placental lipid peroxidation and by determining protective effects of dietary antioxidant quercetin supplementation to reduce HFD-associated placental OS. In this study, female C57BL/6 mice were fed HFD for 1 month before conception and throughout gestation to mimic chronic maternal fast food consumption. Maternal body weight increased from gestation day (GD) 0 to GD19 by 41% with HFD, as compared with 23% in control dams; HFD dams also developed insulin resistance (66% increase in plasma insulin and 27% increase in plasma glucose levels by GD10) as compared with control dams. Placentas from HFD GD19 dams demonstrated loss of trophoblasts and OS-mediated labyrinthine endothelial cellular damage, the latter of which was prevented with quercetin supplementation. Our findings suggest that prenatal HFD alters glucose metabolism and elevates placental OS, which are believed to collectively relate to improper formation of the conceptus and impaired birth outcome.

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Year:  2010        PMID: 20022072     DOI: 10.1016/j.metabol.2009.10.015

Source DB:  PubMed          Journal:  Metabolism        ISSN: 0026-0495            Impact factor:   8.694


  47 in total

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Authors:  Rita S Strakovsky; Yuan-Xiang Pan
Journal:  Antioxid Redox Signal       Date:  2012-01-11       Impact factor: 8.401

2.  Late Cognitive Consequences of Gestational Diabetes to the Offspring, in a New Mouse Model.

Authors:  Ricardo A L de Sousa; Emanuelle V de Lima; Tamara P da Silva; Renata V de Souza; Claudia P Figueiredo; Giselle F Passos; Julia R Clarke
Journal:  Mol Neurobiol       Date:  2019-05-21       Impact factor: 5.590

3.  Choline prevents fetal overgrowth and normalizes placental fatty acid and glucose metabolism in a mouse model of maternal obesity.

Authors:  Juha Nam; Esther Greenwald; Chauntelle Jack-Roberts; Tamara T Ajeeb; Olga V Malysheva; Marie A Caudill; Kathleen Axen; Anjana Saxena; Ekaterina Semernina; Khatia Nanobashvili; Xinyin Jiang
Journal:  J Nutr Biochem       Date:  2017-08-12       Impact factor: 6.048

4.  Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse.

Authors:  Tami J Stuart; Kathleen O'Neill; David Condon; Issac Sasson; Payel Sen; Yunwei Xia; Rebecca A Simmons
Journal:  Biol Reprod       Date:  2018-06-01       Impact factor: 4.285

Review 5.  Placental Origins of Chronic Disease.

Authors:  Graham J Burton; Abigail L Fowden; Kent L Thornburg
Journal:  Physiol Rev       Date:  2016-10       Impact factor: 37.312

6.  A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model.

Authors:  Rita S Strakovsky; Yuan-Xiang Pan
Journal:  Biol Reprod       Date:  2012-03-22       Impact factor: 4.285

7.  Consequences of gestational and pregestational diabetes on placental function and birth weight.

Authors:  Anne Vambergue; Isabelle Fajardy
Journal:  World J Diabetes       Date:  2011-11-15

8.  Exercise Improves Glucose Disposal and Insulin Signaling in Pregnant Mice Fed a High Fat Diet.

Authors:  Lindsay G Carter; Sara Y Ngo Tenlep; Laura A Woollett; Kevin J Pearson
Journal:  J Diabetes Metab       Date:  2015-12-30

9.  Diet-induced impaired glucose tolerance and gestational diabetes in the dog.

Authors:  Mary Courtney Moore; Renuka Menon; Katie C Coate; Maureen Gannon; Marta S Smith; Ben Farmer; Phillip E Williams
Journal:  J Appl Physiol (1985)       Date:  2010-11-18

Review 10.  Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.

Authors:  Frank T Spradley; Ana C Palei; Joey P Granger
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-10-07       Impact factor: 3.619

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