Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Hyperlipidemia: a new therapeutic target for diabetic neuropathy.

Literature DB >> 20021567

Hyperlipidemia: a new therapeutic target for diabetic neuropathy.

Andrea M Vincent¹, Lucy M Hinder, Rodica Pop-Busui, Eva L Feldman.

Abstract

Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 20021567 PMCID： PMC4239691 DOI： 10.1111/j.1529-8027.2009.00237.x

Source DB: PubMed Journal: J Peripher Nerv Syst ISSN： 1085-9489 Impact factor: 3.494

109 in total

1. Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages.

Authors: Y Iwashima; M Eto; A Hata; K Kaku; S Horiuchi; F Ushikubi; H Sano
Journal: Biochem Biophys Res Commun Date: 2000-10-22 Impact factor: 3.575

2. Oxidized lipoproteins activate NF-kappaB binding activity and apoptosis in PC12 cells.

Authors: B Draczynska-Lusiak; Y M Chen; A Y Sun
Journal: Neuroreport Date: 1998-02-16 Impact factor: 1.837

3. Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease.

Authors: B Draczynska-Lusiak; A Doung; A Y Sun
Journal: Mol Chem Neuropathol Date: 1998-02

4. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis.

Authors: S Dimmeler; J Haendeler; J Galle; A M Zeiher
Journal: Circulation Date: 1997-04-01 Impact factor: 29.690

5. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein.

Authors: H Schroeter; R J Williams; R Matin; L Iversen; C A Rice-Evans
Journal: Free Radic Biol Med Date: 2000-12-15 Impact factor: 7.376

6. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy.

Authors: P A Low; K K Nickander; H J Tritschler
Journal: Diabetes Date: 1997-09 Impact factor: 9.461

Review 7. Pathogenesis of diabetic neuropathy.

Authors: E L Feldman; M J Stevens; D A Greene
Journal: Clin Neurosci Date: 1997

8. The effects of intensive glycemic control on neuropathy in the VA cooperative study on type II diabetes mellitus (VA CSDM).

Authors: N Azad; N V Emanuele; C Abraira; W G Henderson; J Colwell; S R Levin; F Q Nuttall; J P Comstock; C T Sawin; C Silbert; F A Rubino
Journal: J Diabetes Complications Date: 1999 Sep-Dec Impact factor: 2.852

9. Serum antioxidant status and oxidized LDL in well-controlled young type 1 diabetic patients with and without subclinical complications.

Authors: D Willems; H Dorchy; D Dufrasne
Journal: Atherosclerosis Date: 1998-04 Impact factor: 5.162

10. Generation, characterization, and histochemical application of monoclonal antibodies selectively recognizing oxidatively modified apoB-containing serum lipoproteins.

Authors: A Hammer; G Kager; G Dohr; H Rabl; I Ghassempur; G Jürgens
Journal: Arterioscler Thromb Vasc Biol Date: 1995-05 Impact factor: 8.311

70 in total

Review 1. Advances in the laboratory evaluation of peripheral neuropathies.

Authors: Mengjing Chloe Huan; Mark Bromberg
Journal: Curr Neurol Neurosci Rep Date: 2012-02 Impact factor: 5.081

2. Long-chain acyl coenzyme A synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction.

Authors: Lucy M Hinder; Claudia Figueroa-Romero; Crystal Pacut; Yu Hong; Anuradha Vivekanandan-Giri; Subramaniam Pennathur; Eva L Feldman
Journal: Antioxid Redox Signal Date: 2013-10-05 Impact factor: 8.401

Hyperlipidemia: a new therapeutic target for diabetic neuropathy.

1. Advanced glycation end products-induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages.

2. Oxidized lipoproteins activate NF-kappaB binding activity and apoptosis in PC12 cells.

3. Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease.

4. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis.

5. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein.

6. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy.

Review 7. Pathogenesis of diabetic neuropathy.

8. The effects of intensive glycemic control on neuropathy in the VA cooperative study on type II diabetes mellitus (VA CSDM).

9. Serum antioxidant status and oxidized LDL in well-controlled young type 1 diabetic patients with and without subclinical complications.

10. Generation, characterization, and histochemical application of monoclonal antibodies selectively recognizing oxidatively modified apoB-containing serum lipoproteins.

Review 1. Advances in the laboratory evaluation of peripheral neuropathies.

2. Long-chain acyl coenzyme A synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction.

Review 3. Diagnosis and treatment of pain in small-fiber neuropathy.

Review 4. Neuropathy in prediabetes: does the clock start ticking early?

5. Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons.

6. Chain length of saturated fatty acids regulates mitochondrial trafficking and function in sensory neurons.

Review 7. Diabetic peripheral neuropathy: should a chaperone accompany our therapeutic approach?

Review 8. Diabetic neuropathy part 1: overview and symmetric phenotypes.

9. Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons.

10. Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology.