PURPOSE: The study aimed at collecting regional data to support and establish evidence-based decision-making. METHODS: We investigated a cohort of 154 preterm infants with gestational age <27+0 weeks born between 1997 and 1999 in a defined region of Northern Germany regarding neurosensory and cognitive outcomes, overall disability status, behavioral problems, and health-related quality of life at the age of seven to nine years (mean: eight years, SD seven months). RESULTS: 92 (60%) infants survived, 75 of these 92 (82%) were followed-up. Rates of disability were high: only 27 (36%) showed 'no dysfunction' of neurosensory status, 33 (44%) 'mild dysfunction', 5 (7%) 'moderate dysfunction' and 10 (13%) 'severe dysfunction', including 8 (11%) with non-ambulatory cerebral palsy. 19 (26%) were mentally retarded. Parents reported behavioral problems in 21 (28%), health-related quality of life was lower in preterm infants compared to a representative normal sample. In multivariate analyses IVH III-IV/PVL was an independent risk factor for adverse outcomes. Behavior problems were predicted by low IQ and lower educational level of the mother. CONCLUSIONS: Overall our results confirm high levels of mortality and morbidity in extremely immature infants. Regional data should include mortality, morbidity and health-related quality of life to adequately inform parents about the prognosis.
PURPOSE: The study aimed at collecting regional data to support and establish evidence-based decision-making. METHODS: We investigated a cohort of 154 preterm infants with gestational age <27+0 weeks born between 1997 and 1999 in a defined region of Northern Germany regarding neurosensory and cognitive outcomes, overall disability status, behavioral problems, and health-related quality of life at the age of seven to nine years (mean: eight years, SD seven months). RESULTS: 92 (60%) infants survived, 75 of these 92 (82%) were followed-up. Rates of disability were high: only 27 (36%) showed 'no dysfunction' of neurosensory status, 33 (44%) 'mild dysfunction', 5 (7%) 'moderate dysfunction' and 10 (13%) 'severe dysfunction', including 8 (11%) with non-ambulatory cerebral palsy. 19 (26%) were mentally retarded. Parents reported behavioral problems in 21 (28%), health-related quality of life was lower in preterm infants compared to a representative normal sample. In multivariate analyses IVH III-IV/PVL was an independent risk factor for adverse outcomes. Behavior problems were predicted by low IQ and lower educational level of the mother. CONCLUSIONS: Overall our results confirm high levels of mortality and morbidity in extremely immature infants. Regional data should include mortality, morbidity and health-related quality of life to adequately inform parents about the prognosis.
Authors: Rachel G Hirschberger; Karl C K Kuban; Thomas M O'Shea; Robert M Joseph; Tim Heeren; Laurie M Douglass; Carl E Stafstrom; Hernan Jara; Jean A Frazier; Deborah Hirtz; Julie V Rollins; Nigel Paneth Journal: Pediatr Neurol Date: 2017-11-13 Impact factor: 3.372
Authors: Karl C K Kuban; Robert M Joseph; Thomas M O'Shea; Elizabeth N Allred; Timothy Heeren; Laurie Douglass; Carl E Stafstrom; Hernan Jara; Jean A Frazier; Deborah Hirtz; Alan Leviton Journal: J Pediatr Date: 2016-03-19 Impact factor: 4.406
Authors: Marie-Ange Einaudi; Marie-Claude Simeoni; Catherine Gire; Pierre Le Coz; Sophie Condopoulos; Pascal Auquier Journal: Health Qual Life Outcomes Date: 2012-09-28 Impact factor: 3.186
Authors: Louise Linsell; Reem Malouf; Samantha Johnson; Joan Morris; Jennifer J Kurinczuk; Neil Marlow Journal: J Dev Behav Pediatr Date: 2016-01 Impact factor: 2.225