Ei Tae Kim1, Lee Hoo Kim1, Jung Il Lee2, Hee Seung Chin3,4. 1. Department of Ophthalmology, Inha University School of Medicine, Incheon, Korea. 2. Division of Gastroenterology, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea. 3. Department of Ophthalmology, Inha University School of Medicine, Incheon, Korea. hschin@inha.ac.kr. 4. Department of Ophthalmology, Inha University Hospital, #7-206 Shinheung-Dong, Jung-Gu, Incheon, 400-711, Korea. hschin@inha.ac.kr.
Abstract
BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients. METHODS: Thirty-two patients with chronic hepatitis C were examined prospectively for changes in fundus findings while they were being treated with pegylated interferon and ribavirin. Patients were followed with sequential ocular examinations for a maximum of 36 weeks. RESULTS: Eleven of the 32 patients (34.4%) developed retinopathy. Cotton-wool spots were found in six patients, retinal hemorrhages in four, and branch retinal vein occlusion in one (one eye). Hypertension was found to be the most significant risk factor for developing retinopathy. CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon. The valid risk factor for developing retinopathy is hypertension. The high rate of retinopathy in patients with hypertension suggests that patients should be carefully monitored.
BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis Cpatients. METHODS: Thirty-two patients with chronic hepatitis C were examined prospectively for changes in fundus findings while they were being treated with pegylated interferon and ribavirin. Patients were followed with sequential ocular examinations for a maximum of 36 weeks. RESULTS: Eleven of the 32 patients (34.4%) developed retinopathy. Cotton-wool spots were found in six patients, retinal hemorrhages in four, and branch retinal vein occlusion in one (one eye). Hypertension was found to be the most significant risk factor for developing retinopathy. CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon. The valid risk factor for developing retinopathy is hypertension. The high rate of retinopathy in patients with hypertension suggests that patients should be carefully monitored.
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