Literature DB >> 20019886

Molecular MRI of Atherosclerotic Plaque With Targeted Contrast Agents.

David E Sosnovik, Peter Caravan.   

Abstract

Molecular MRI of atherosclerosis involves the use of novel contrast agents to image cellular and molecular processes within atherosclerotic plaque. Agents to image plaque lipid content, inflammation, angiogenesis, and thrombosis have been developed and studied extensively in animal models of atherosclerosis and vascular injury. Selected agents have also been studied in humans, with highly promising initial results. In this brief review, recent advances as well as opportunities and challenges in the field are discussed.

Entities:  

Year:  2009        PMID： 20019886      PMCID： PMC2794433          DOI： 10.1007/s12410-009-0012-y

Source DB:  PubMed          Journal:  Curr Cardiovasc Imaging Rep        ISSN： 1941-9074


  44 in total

Review 1.  Molecular and cellular imaging of atherosclerosis: emerging applications.

Authors:  Farouc A Jaffer; Peter Libby; Ralph Weissleder
Journal:  J Am Coll Cardiol       Date:  2006-03-20       Impact factor: 24.094

2.  Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON).

Authors:  Matthias Stuber; Wesley D Gilson; Michael Schär; Dorota A Kedziorek; Lawrence V Hofmann; Saurabh Shah; Evert-Jan Vonken; Jeff W M Bulte; Dara L Kraitchman
Journal:  Magn Reson Med       Date:  2007-11       Impact factor: 4.668

Review 3.  Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.

Authors:  David E Sosnovik; Matthias Nahrendorf; Ralph Weissleder
Journal:  Basic Res Cardiol       Date:  2008-03       Impact factor: 17.165

4.  Molecular magnetic resonance imaging of pulmonary emboli with a fibrin-specific contrast agent.

Authors:  Elmar Spuentrup; Marcus Katoh; Andrea J Wiethoff; Edward C Parsons; Rene M Botnar; Andreas H Mahnken; Rolf W Günther; Arno Buecker
Journal:  Am J Respir Crit Care Med       Date:  2005-06-03       Impact factor: 21.405

Review 5.  Atherothrombosis and high-risk plaque: part I: evolving concepts.

Authors:  Valentin Fuster; Pedro R Moreno; Zahi A Fayad; Roberto Corti; Juan J Badimon
Journal:  J Am Coll Cardiol       Date:  2005-09-20       Impact factor: 24.094

6.  Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.

Authors:  Matthias Nahrendorf; Farouc A Jaffer; Kimberly A Kelly; David E Sosnovik; Elena Aikawa; Peter Libby; Ralph Weissleder
Journal:  Circulation       Date:  2006-09-25       Impact factor: 29.690

7.  Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles.

Authors:  Patrick M Winter; Anne M Morawski; Shelton D Caruthers; Ralph W Fuhrhop; Huiying Zhang; Todd A Williams; John S Allen; Elizabeth K Lacy; J David Robertson; Gregory M Lanza; Samuel A Wickline
Journal:  Circulation       Date:  2003-10-13       Impact factor: 29.690

8.  Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis.

Authors:  C von zur Muhlen; D von Elverfeldt; J A Moeller; R P Choudhury; D Paul; C E Hagemeyer; M Olschewski; A Becker; I Neudorfer; N Bassler; M Schwarz; C Bode; K Peter
Journal:  Circulation       Date:  2008-06-23       Impact factor: 29.690

9.  MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients.

Authors:  Elmar Spuentrup; Rene M Botnar; Andrea J Wiethoff; Tareq Ibrahim; Sebastian Kelle; Marcus Katoh; Murat Ozgun; Eike Nagel; Josef Vymazal; Phil B Graham; Rolf W Günther; David Maintz
Journal:  Eur Radiol       Date:  2008-04-19       Impact factor: 5.315

10.  In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI.

Authors:  Rikin A Trivedi; Jean-Marie U-King-Im; Martin J Graves; Justin J Cross; Jo Horsley; Martin J Goddard; Jeremy N Skepper; George Quartey; Elizabeth Warburton; Ilse Joubert; Liqun Wang; Peter J Kirkpatrick; John Brown; Jonathan H Gillard
Journal:  Stroke       Date:  2004-05-27       Impact factor: 7.914
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  4 in total

Review 1.  Cardiovascular molecular imaging: focus on clinical translation.

Authors:  Ian Y Chen; Joseph C Wu
Journal:  Circulation       Date:  2011-02-01       Impact factor: 29.690

2.  Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques.

Authors:  Chuqiao Tu; Thomas S C Ng; Hargun K Sohi; Heather A Palko; Adrian House; Russell E Jacobs; Angelique Y Louie
Journal:  Biomaterials       Date:  2011-07-13       Impact factor: 12.479

Review 3.  Emerging MRI methods in translational cardiovascular research.

Authors:  Moriel H Vandsburger; Frederick H Epstein
Journal:  J Cardiovasc Transl Res       Date:  2011-03-31       Impact factor: 4.132

Review 4.  Assessment of multifunctional contrast agent probes in neuroimaging: Implications of nanopharmaceutical therapeutic interventions.

Authors:  Lina H Machtoub
Journal:  J Adv Pharm Technol Res       Date:  2013-07
  4 in total

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