Literature DB >> 2001985

L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity.

F VanMiddlesworth1, M N Omstead, D Schmatz, K Bartizal, R Fromtling, G Bills, K Nollstadt, S Honeycutt, M Zweerink, G Garrity.   

Abstract

A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

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Year:  1991        PMID： 2001985     DOI： 10.7164/antibiotics.44.45

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  14 in total

1.  Total Synthesis of (+)-Papulacandin D.

Authors:  Scott E Denmark; Tetsuya Kobayashi; Christopher S Regens
Journal:  Tetrahedron       Date:  2010-06-26       Impact factor: 2.457

2.  Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.

Authors:  J Onishi; M Meinz; J Thompson; J Curotto; S Dreikorn; M Rosenbach; C Douglas; G Abruzzo; A Flattery; L Kong; A Cabello; F Vicente; F Pelaez; M T Diez; I Martin; G Bills; R Giacobbe; A Dombrowski; R Schwartz; S Morris; G Harris; A Tsipouras; K Wilson; M B Kurtz
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

Review 3.  Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2005-03       Impact factor: 1.880

Review 4.  Compounds active against cell walls of medically important fungi.

Authors:  R F Hector
Journal:  Clin Microbiol Rev       Date:  1993-01       Impact factor: 26.132

5.  Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.

Authors:  M B Kurtz; G Abruzzo; A Flattery; K Bartizal; J A Marrinan; W Li; J Milligan; K Nollstadt; C M Douglas
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

6.  Nikkomycin Z supersensitivity of an echinocandin-resistant mutant of Saccharomyces cerevisiae.

Authors:  M el-Sherbeini; J A Clemas
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

7.  Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

Authors:  M B Kurtz; C Douglas; J Marrinan; K Nollstadt; J Onishi; S Dreikorn; J Milligan; S Mandala; J Thompson; J M Balkovec
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191

8.  Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia.

Authors:  Michael J Linke; Alan Ashbaugh; Margaret S Collins; Keeley Lynch; Melanie T Cushion
Journal:  Infect Immun       Date:  2013-01-14       Impact factor: 3.441

9.  A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.

Authors:  C M Douglas; J A Marrinan; W Li; M B Kurtz
Journal:  J Bacteriol       Date:  1994-09       Impact factor: 3.490

10.  Cloning and characterization of GNS1: a Saccharomyces cerevisiae gene involved in synthesis of 1,3-beta-glucan in vitro.

Authors:  M el-Sherbeini; J A Clemas
Journal:  J Bacteriol       Date:  1995-06       Impact factor: 3.490
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