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Literature DB >> 20019184

Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas.

Abstract

Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration. The complexity of the signaling pathways initiating and terminating this process have provided paradigms for regenerative medicine. Many aspects of the signaling mechanisms involved in hepatic regeneration are under active investigation. The purpose of this review is to focus on the areas still not well understood. The review also aims to provide insights into the ways by which current concepts of liver regeneration can provide understanding regarding malfunction of the regenerative process in liver diseases, such as acute liver failure.

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 20019184 PMCID： PMC2797862 DOI： 10.2353/ajpath.2010.090675

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

125 in total

1. EFFECT OF PARTIAL HEPATECTOMY ON DNA SYNTHESIS AND MITOSIS IN HETEROTOPIC PARTIAL AUTOGRAFTS OF RAT LIVER.

Authors: G F LEONG; J W GRISHAM; B V HOLE; M L ALBRIGHT
Journal: Cancer Res Date: 1964-09 Impact factor: 12.701

2. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR.

Authors: Melissa A Passino; Ryan A Adams; Shoana L Sikorski; Katerina Akassoglou
Journal: Science Date: 2007-03-30 Impact factor: 47.728

3. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor.

Authors: Y Yamada; I Kirillova; J J Peschon; N Fausto
Journal: Proc Natl Acad Sci U S A Date: 1997-02-18 Impact factor: 11.205

4. Platelet-derived serotonin mediates liver regeneration.

Authors: Mickael Lesurtel; Rolf Graf; Boris Aleil; Diego J Walther; Yinghua Tian; Wolfram Jochum; Christian Gachet; Michael Bader; Pierre-Alain Clavien
Journal: Science Date: 2006-04-07 Impact factor: 47.728

5. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

Authors: N Sanderson; V Factor; P Nagy; J Kopp; P Kondaiah; L Wakefield; A B Roberts; M B Sporn; S S Thorgeirsson
Journal: Proc Natl Acad Sci U S A Date: 1995-03-28 Impact factor: 11.205

6. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter.

Authors: Y Liu; G K Michalopoulos; R Zarnegar
Journal: J Biol Chem Date: 1994-02-11 Impact factor: 5.157

7. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.

Authors: G Pilia; R M Hughes-Benzie; A MacKenzie; P Baybayan; E Y Chen; R Huber; G Neri; A Cao; A Forabosco; D Schlessinger
Journal: Nat Genet Date: 1996-03 Impact factor: 38.330

8. Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liver.

Authors: A Masumoto; N Yamamoto
Journal: Biochem Biophys Res Commun Date: 1991-01-15 Impact factor: 3.575

9. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor.

Authors: Y Yamada; E M Webber; I Kirillova; J J Peschon; N Fausto
Journal: Hepatology Date: 1998-10 Impact factor: 17.425

10. Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor.

Authors: Y Liu; G K Michalopoulos; R Zarnegar
Journal: Biochim Biophys Acta Date: 1993-11-16

279 in total

1. S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.

Authors: Catherine Espeillac; Claudia Mitchell; Séverine Celton-Morizur; Céline Chauvin; Vonda Koka; Cynthia Gillet; Jeffrey H Albrecht; Chantal Desdouets; Mario Pende
Journal: J Clin Invest Date: 2011-07 Impact factor: 14.808

2. Impaired hepatocellular regeneration in murine sepsis is dependent on regulatory protein levels.

Authors: Arnoley Abcejo; Kenneth M Andrejko; E Andrew Ochroch; Nichelle R Raj; Clifford S Deutschman
Journal: Shock Date: 2011-11 Impact factor: 3.454

3. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Authors: Shashikiran Donthamsetty; Vishakha S Bhave; Corrine S Kliment; William C Bowen; Wendy M Mars; Aaron W Bell; Rachel E Stewart; Anne Orr; Chuanyue Wu; George K Michalopoulos
Journal: Hepatology Date: 2011-01-06 Impact factor: 17.425

Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas.

1. EFFECT OF PARTIAL HEPATECTOMY ON DNA SYNTHESIS AND MITOSIS IN HETEROTOPIC PARTIAL AUTOGRAFTS OF RAT LIVER.

2. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR.

3. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor.

4. Platelet-derived serotonin mediates liver regeneration.

5. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

6. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter.

7. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.

8. Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liver.

9. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor.

10. Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor.

1. S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.

2. Impaired hepatocellular regeneration in murine sepsis is dependent on regulatory protein levels.

3. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

4. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats.

5. Phenotypic fidelity (or not?) of epithelial cells in the liver.

Review 6. [Small-for-size: experimental findings for liver surgery].

7. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration.

Review 8. A critical appraisal of the hemodynamic signal driving liver regeneration.

9. Esophagus and regenerative medicine.

10. Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.