BACKGROUND AND OBJECTIVES: Health-related quality of life (HRQOL) is a measure of the well being of hemodialysis patients and an independent prognostic predictor. Our aim was to determine whether HRQOL among hemodialysis patients has changed over time. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We retrospectively analyzed data collected by Dialysis Clinic, Inc. from adult patients starting hemodialysis between January 1, 1997 and May 31, 2006. The primary outcome was HRQOL assessed by Short Form 36, 6 to 18 months after and closest to the 1-year anniversary of starting hemodialysis. Secular trends were analyzed by linear regression for continuous variables and logistic regression for categorical ones. Year of starting dialysis was the predictor. A five-point difference on a 0 to 100 scale was considered clinically significant. RESULTS: Short Form 36 scores were available for 11,079 patients. Role physical, general health, vitality, social functioning, and physical component summary scores were unchanged among patients over the study period. Statistically significant (P < 0.05) but clinically insignificant changes were observed in physical functioning (-0.2 points/yr), bodily pain (+0.2 points/yr), mental health (+0.15 points/yr), and mental component summary scores (+0.13 points/yr). Only role emotional showed clinically significant improvement. Trends were unchanged after adjusting for age, gender, race, diabetes, hemoglobin, phosphorous, Kt/V, and albumin. CONCLUSIONS: Most HRQOL domains showed either no statistically significant change or statistically but not clinically significant change over almost a decade. These results suggest that, despite important developments in hemodialysis care since 1997, little progress was made in improving HRQOL of hemodialysis patients.
BACKGROUND AND OBJECTIVES: Health-related quality of life (HRQOL) is a measure of the well being of hemodialysis patients and an independent prognostic predictor. Our aim was to determine whether HRQOL among hemodialysis patients has changed over time. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We retrospectively analyzed data collected by Dialysis Clinic, Inc. from adult patients starting hemodialysis between January 1, 1997 and May 31, 2006. The primary outcome was HRQOL assessed by Short Form 36, 6 to 18 months after and closest to the 1-year anniversary of starting hemodialysis. Secular trends were analyzed by linear regression for continuous variables and logistic regression for categorical ones. Year of starting dialysis was the predictor. A five-point difference on a 0 to 100 scale was considered clinically significant. RESULTS: Short Form 36 scores were available for 11,079 patients. Role physical, general health, vitality, social functioning, and physical component summary scores were unchanged among patients over the study period. Statistically significant (P < 0.05) but clinically insignificant changes were observed in physical functioning (-0.2 points/yr), bodily pain (+0.2 points/yr), mental health (+0.15 points/yr), and mental component summary scores (+0.13 points/yr). Only role emotional showed clinically significant improvement. Trends were unchanged after adjusting for age, gender, race, diabetes, hemoglobin, phosphorous, Kt/V, and albumin. CONCLUSIONS: Most HRQOL domains showed either no statistically significant change or statistically but not clinically significant change over almost a decade. These results suggest that, despite important developments in hemodialysis care since 1997, little progress was made in improving HRQOL of hemodialysis patients.
Authors: Fuensanta Moreno; Dámaso Sanz-Guajardo; Juan Manuel López-Gómez; Rosa Jofre; Fernando Valderrábano Journal: J Am Soc Nephrol Date: 2000-02 Impact factor: 10.121
Authors: Antonio Alberto Lopes; Jennifer L Bragg-Gresham; Sudtida Satayathum; Keith McCullough; Trinh Pifer; David A Goodkin; Donna L Mapes; Eric W Young; Robert A Wolfe; Philip J Held; Friedrich K Port Journal: Am J Kidney Dis Date: 2003-03 Impact factor: 8.860
Authors: Mark Unruh; Robert Benz; Tom Greene; Guofen Yan; Srinivasan Beddhu; Maria DeVita; Johanna T Dwyer; Paul L Kimmel; John W Kusek; Alice Martin; Josephine Rehm-McGillicuddy; Brendan P Teehan; Klemens B Meyer Journal: Kidney Int Date: 2004-07 Impact factor: 10.612
Authors: William M McClellan; Diane L Frankenfield; Pamela R Frederick; Steven D Helgerson; Jay B Wish; Jonathan R Sugarman Journal: Health Care Financ Rev Date: 2003
Authors: Jeffrey Perl; Angelo Karaboyas; Hal Morgenstern; Ananda Sen; Hugh C Rayner; Raymond C Vanholder; Christian Combe; Takeshi Hasegawa; Fredric O Finkelstein; Antonio A Lopes; Bruce M Robinson; Ronald L Pisoni; Francesca Tentori Journal: Nephrol Dial Transplant Date: 2017-03-01 Impact factor: 5.992
Authors: Paulo Roberto Santos; Ítala Mônica de Sales Santos; João Laerte Alves de Freitas Filho; Carlos Wellington Macha; Priscila Garcia Câmara Cabral Tavares; Ana Cláudia de Oliveira Portela; Ana Mayara Barros Campos; Ana Raquel Ferreira de Azevedo; Catarine Cavalcante Ary; Felipe Peixoto Nobre; Jamille Fernandes Carneiro; Yandra Maria Gomes Pontes Journal: Int Urol Nephrol Date: 2017-05-18 Impact factor: 2.370
Authors: Manisha Jhamb; Francis Pike; Sarah Ramer; Christos Argyropoulos; Jennifer Steel; Mary Amanda Dew; Steven D Weisbord; Lisa Weissfeld; Mark Unruh Journal: Am J Nephrol Date: 2011-05-09 Impact factor: 3.754
Authors: Ea Wha Kang; Francis Pike; Sarah Ramer; Khaled Abdel-Kader; Larissa Myaskovsky; Mary Amanda Dew; Mark Unruh Journal: Clin J Am Soc Nephrol Date: 2012-04-05 Impact factor: 8.237
Authors: Mark L Unruh; Brett Larive; Glenn M Chertow; Paul W Eggers; Amit X Garg; Jennifer Gassman; Maria Tarallo; Fredric O Finkelstein; Paul L Kimmel Journal: Am J Kidney Dis Date: 2013-01-15 Impact factor: 8.860
Authors: Martin Wagner; Johannes Krämer; Elisabeth Blohm; Dorothee Vergho; Frank Weidemann; Frank Breunig; Christoph Wanner Journal: BMC Nephrol Date: 2014-11-29 Impact factor: 2.388