| Literature DB >> 200191 |
Abstract
Cyclic AMP and dibutyryl cyclic AMP as well as several 8-substituted analogs of cyclic AMP inhibited in vitro human blood neutrophil chemotaxis. Cyclic GMP enhanced chemotaxis. 8-substitution on the cyclic GMP nucleus markedly dampened the cyclic GMP effect. SQ 20,009, a potent phosphodiesterase inhibitor when tested alone inhibited chemotaxis; it potentiated the inhibition or enhancement of chemotaxis when combined with cyclic AMP or cyclic GMP, respectively.Entities:
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Year: 1977 PMID： 200191
Source DB: PubMed Journal: Arch Int Pharmacodyn Ther ISSN： 0003-9780