| Literature DB >> 20018373 |
Marianne Eyholzer1, Sabine Schmid, Julian A Schardt, Simon Haefliger, Beatrice U Mueller, Thomas Pabst.
Abstract
microRNA-223 (miR-223) can trigger normal granulopoiesis. miR-223 expression is regulated by two distinct CEBPA (CCAAT/enhancer binding protein-alpha) sites. Here, we report that miR-223 is largely suppressed in cells from acute myeloid leukemia (AML) patients. By sequencing, we found that miR-223 suppression in AML is not caused by DNA sequence alterations, nor is it mediated by promoter hypermethylation. The analysis of the individual contribution of both CEBPA sites to miR-223 regulation identified the site upstream of the miR-223 primary transcript as the predominant regulatory element. Our results suggest that miR-223 suppression in AML is caused by impaired miR-223 upstream factors. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20018373 DOI： 10.1016/j.leukres.2009.11.019
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156