Sinisa Car1, Vladimir Trkulja. 1. Department of internal medicine, Varazdin County General Hospital, Ivana Mestrovica bb, 42000 Varazdin, Croatia. sinisa.car@vz.t-com.hr
Abstract
AIM: To assess serum uric acid (SUA) levels determined on admission as a potential predictor of short-term mortality and long-term survival in acute myocardial infarction (AMI) patients. METHOD: Data for this retrospective prognostic study were drawn from the patient database of the Varazdin County General Hospital in Varazdin, Croatia. We included consecutive patients with verified AMI admitted within 48 hours since the symptom onset during the period between 1 January 1996 and 31 December 2001. Long-term survival/mortality data were collected through direct contacts with patients and search of the community death registries. Relative risks (RR) and hazard ratios (HR) by 10 micromol/L increase in SUA were determined using modified Poisson regression with robust error variance and proportional hazard regression, respectively. RESULTS: A total of 621 patients (age 27-90 years, 64.7% men, 77.5% AMI with ST elevation, SUA 63-993 micromol/L) were included. Higher SUA on admission was independently associated with higher in-hospital mortality (RR, 1.016; 95% confidence interval [CI], 1.001-1.031, P=0.043) and higher thirty-day mortality (RR, 1.016; 95% CI, 1.003-1.029, P=0.018). Considered covariates were demographics, pre-index event cardiovascular morbidity and treatment, on-admission serum creatinine, total cholesterol and triglycerides, AMI characteristics, and peak creatine phosphokinase. Higher SUA on admission was also independently associated with poorer long-term survival (ie, higher all-cause mortality) (HR, 1.105; 95% CI, 1.020-1.195, P=0.010). Considered covariates were demographics, laboratory variables on admission, AMI characteristics, peak creatine phosphokinase, acute complications, and treatment at discharge. CONCLUSION: Higher serum uric acid determined on admission is associated with higher in-hospital mortality and thirty-day mortality and poorer long-term survival after AMI.
AIM: To assess serum uric acid (SUA) levels determined on admission as a potential predictor of short-term mortality and long-term survival in acute myocardial infarction (AMI) patients. METHOD: Data for this retrospective prognostic study were drawn from the patient database of the Varazdin County General Hospital in Varazdin, Croatia. We included consecutive patients with verified AMI admitted within 48 hours since the symptom onset during the period between 1 January 1996 and 31 December 2001. Long-term survival/mortality data were collected through direct contacts with patients and search of the community death registries. Relative risks (RR) and hazard ratios (HR) by 10 micromol/L increase in SUA were determined using modified Poisson regression with robust error variance and proportional hazard regression, respectively. RESULTS: A total of 621 patients (age 27-90 years, 64.7% men, 77.5% AMI with ST elevation, SUA 63-993 micromol/L) were included. Higher SUA on admission was independently associated with higher in-hospital mortality (RR, 1.016; 95% confidence interval [CI], 1.001-1.031, P=0.043) and higher thirty-day mortality (RR, 1.016; 95% CI, 1.003-1.029, P=0.018). Considered covariates were demographics, pre-index event cardiovascular morbidity and treatment, on-admission serum creatinine, total cholesterol and triglycerides, AMI characteristics, and peak creatine phosphokinase. Higher SUA on admission was also independently associated with poorer long-term survival (ie, higher all-cause mortality) (HR, 1.105; 95% CI, 1.020-1.195, P=0.010). Considered covariates were demographics, laboratory variables on admission, AMI characteristics, peak creatine phosphokinase, acute complications, and treatment at discharge. CONCLUSION: Higher serum uric acid determined on admission is associated with higher in-hospital mortality and thirty-day mortality and poorer long-term survival after AMI.
Authors: Cheuk-Kit Wong; Ralph A H Stewart; Wanzhen Gao; John K French; Christopher Raffel; Harvey D White Journal: Eur Heart J Date: 2005-11-03 Impact factor: 29.983
Authors: H J Milionis; K J Kalantzi; J A Goudevenos; K Seferiadis; D P Mikhailidis; M S Elisaf Journal: J Intern Med Date: 2005-11 Impact factor: 8.989
Authors: Yafim Brodov; Pierre Chouraqui; Ilan Goldenberg; Valentina Boyko; Lori Mandelzweig; Shlomo Behar Journal: Cardiology Date: 2009-09-23 Impact factor: 1.869
Authors: Asterios Karagiannis; Dimitri P Mikhailidis; Konstantinos Tziomalos; Maria Sileli; Savvas Savvatianos; Anna Kakafika; Thomas Gossios; Napoleon Krikis; Irene Moschou; Michael Xochellis; Vassilios G Athyros Journal: Circ J Date: 2007-07 Impact factor: 2.993
Authors: Veronique Vitart; Igor Rudan; Caroline Hayward; Nicola K Gray; James Floyd; Colin N A Palmer; Sara A Knott; Ivana Kolcic; Ozren Polasek; Juergen Graessler; James F Wilson; Anthony Marinaki; Philip L Riches; Xinhua Shu; Branka Janicijevic; Nina Smolej-Narancic; Barbara Gorgoni; Joanne Morgan; Susan Campbell; Zrinka Biloglav; Lovorka Barac-Lauc; Marijana Pericic; Irena Martinovic Klaric; Lina Zgaga; Tatjana Skaric-Juric; Sarah H Wild; William A Richardson; Peter Hohenstein; Charley H Kimber; Albert Tenesa; Louise A Donnelly; Lynette D Fairbanks; Martin Aringer; Paul M McKeigue; Stuart H Ralston; Andrew D Morris; Pavao Rudan; Nicholas D Hastie; Harry Campbell; Alan F Wright Journal: Nat Genet Date: 2008-03-09 Impact factor: 38.330
Authors: Ana T Timóteo; Ana Lousinha; Jorge Labandeiro; Fernando Miranda; Ana L Papoila; José A Oliveira; Maria L Ferreira; Rui C Ferreira Journal: Eur Heart J Acute Cardiovasc Care Date: 2013-03