Literature DB >> 20016493

Protein folding: sticky N17 speeds huntingtin pile-up.

Susan W Liebman, Stephen C Meredith.   

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Year:  2010        PMID： 20016493     DOI： 10.1038/nchembio.279

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  7 in total

1.  Oligoproline effects on polyglutamine conformation and aggregation.

Authors:  Anusri Bhattacharyya; Ashwani K Thakur; Veronique M Chellgren; Geetha Thiagarajan; Angela D Williams; Brian W Chellgren; Trevor P Creamer; Ronald Wetzel
Journal:  J Mol Biol       Date:  2005-11-09       Impact factor: 5.469

2.  Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure.

Authors:  Reed B Wickner; Fred Dyda; Robert Tycko
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-11       Impact factor: 11.205

3.  The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

Authors:  Stephen Tam; Ron Geller; Christoph Spiess; Judith Frydman
Journal:  Nat Cell Biol       Date:  2006-09-17       Impact factor: 28.824

4.  Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure.

Authors:  Gregory Darnell; Joseph P R O Orgel; Reinhard Pahl; Stephen C Meredith
Journal:  J Mol Biol       Date:  2007-09-14       Impact factor: 5.469

5.  The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation.

Authors:  Nicholas W Kelley; Xuhui Huang; Stephen Tam; Christoph Spiess; Judith Frydman; Vijay S Pande
Journal:  J Mol Biol       Date:  2009-01-23       Impact factor: 5.469

6.  Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

Authors:  Ashwani K Thakur; Murali Jayaraman; Rakesh Mishra; Monika Thakur; Veronique M Chellgren; In-Ja L Byeon; Dalaver H Anjum; Ravindra Kodali; Trevor P Creamer; James F Conway; Angela M Gronenborn; Ronald Wetzel
Journal:  Nat Struct Mol Biol       Date:  2009-03-08       Impact factor: 15.369

7.  The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation.

Authors:  Stephen Tam; Christoph Spiess; William Auyeung; Lukasz Joachimiak; Bryan Chen; Michelle A Poirier; Judith Frydman
Journal:  Nat Struct Mol Biol       Date:  2009-11-15       Impact factor: 15.369
  7 in total
  12 in total

Review 1.  Polyglutamine misfolding in yeast: toxic and protective aggregation.

Authors:  Martin L Duennwald
Journal:  Prion       Date:  2011-10-01       Impact factor: 3.931

2.  Stable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers.

Authors:  Markus S Miettinen; Luca Monticelli; Praveen Nedumpully-Govindan; Volker Knecht; Zoya Ignatova
Journal:  Biophys J       Date:  2014-04-15       Impact factor: 4.033

Review 3.  Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?

Authors:  Guylaine Hoffner; Philippe Djian
Journal:  Mol Neurobiol       Date:  2014-10-22       Impact factor: 5.590

4.  The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.

Authors:  V N Sivanandam; Murali Jayaraman; Cody L Hoop; Ravindra Kodali; Ronald Wetzel; Patrick C A van der Wel
Journal:  J Am Chem Soc       Date:  2011-03-07       Impact factor: 15.419

5.  Probing the Huntingtin 1-17 membrane anchor on a phospholipid bilayer by using all-atom simulations.

Authors:  Sébastien Côté; Vincent Binette; Evgeniy S Salnikov; Burkhard Bechinger; Normand Mousseau
Journal:  Biophys J       Date:  2015-03-10       Impact factor: 4.033

6.  Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous Solution.

Authors:  Vincent Binette; Sébastien Côté; Normand Mousseau
Journal:  Biophys J       Date:  2016-03-08       Impact factor: 4.033

7.  Trinucleotide repeats: a structural perspective.

Authors:  Bruno Almeida; Sara Fernandes; Isabel A Abreu; Sandra Macedo-Ribeiro
Journal:  Front Neurol       Date:  2013-06-20       Impact factor: 4.003

8.  TRiC's tricks inhibit huntingtin aggregation.

Authors:  Sarah H Shahmoradian; Jesus G Galaz-Montoya; Michael F Schmid; Yao Cong; Boxue Ma; Christoph Spiess; Judith Frydman; Steven J Ludtke; Wah Chiu
Journal:  Elife       Date:  2013-07-09       Impact factor: 8.140

9.  Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.

Authors:  Valentina Fodale; Natalie C Kegulian; Margherita Verani; Cristina Cariulo; Lucia Azzollini; Lara Petricca; Manuel Daldin; Roberto Boggio; Alessandro Padova; Rainer Kuhn; Robert Pacifici; Douglas Macdonald; Ryan C Schoenfeld; Hyunsun Park; J Mario Isas; Ralf Langen; Andreas Weiss; Andrea Caricasole
Journal:  PLoS One       Date:  2014-12-02       Impact factor: 3.240

10.  Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansion.

Authors:  Guylaine Hoffner; Philippe Djian
Journal:  Brain Sci       Date:  2014-03-03
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