| Literature DB >> 20015649 |
Spiros Liras1, Stanton F McHardy, Martin P Allen, Barb E Segelstein, Steven D Heck, Dianne K Bryce, Anne W Schmidt, Michelle Vanase-Frawley, Ernesto Callegari, Stafford McLean.
Abstract
The design and synthesis of novel opiates are reported. Based on the message-address principle a novel class of 4,4- and 3,3-biaryl piperidines was designed and synthesized. Biological evaluation confirmed that these compounds exhibit high affinity and selectivity for the delta opioid receptor. Key structure-activity relationships that influence affinity, selectivity, functional activity and clearance are reported. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20015649 DOI： 10.1016/j.bmcl.2009.11.113
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823