Literature DB >> 20015626

Coordination to gallium(III) strongly enhances the potency of 2-pyridineformamide thiosemicarbazones against Cryptococcus opportunistic fungi.

Thaíssa de Oliveira Bastos1, Betânia Maria Soares, Patrícia Silva Cisalpino, Isolda Castro Mendes, Raquel Gouvea dos Santos, Heloisa Beraldo.   

Abstract

A family of 2-pyridineformamide-derived thiosemicarbazones and their gallium(III) complexes were tested against several isolates of pathogenic Cryptococcus strains. On complexation the antifungal activity significantly increases, suggesting coordination to gallium(III) to be an interesting strategy of antifungal dose reduction. 2009 Elsevier GmbH. All rights reserved.

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Year:  2009        PMID: 20015626     DOI: 10.1016/j.micres.2009.10.005

Source DB:  PubMed          Journal:  Microbiol Res        ISSN: 0944-5013            Impact factor:   5.415


  6 in total

1.  Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules.

Authors:  Floyd A Beckford; Alyssa Brock; Antonio Gonzalez-Sarrías; Navindra P Seeram
Journal:  J Mol Struct       Date:  2016-05-24       Impact factor: 3.196

Review 2.  Medical applications and toxicities of gallium compounds.

Authors:  Christopher R Chitambar
Journal:  Int J Environ Res Public Health       Date:  2010-05-10       Impact factor: 3.390

3.  A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study.

Authors:  Adel M F Alhalawani; Declan J Curran; Belinda Pingguan-Murphy; Daniel Boyd; Mark R Towler
Journal:  J Funct Biomater       Date:  2013-11-21

4.  Repurposing an inhibitor of ribosomal biogenesis with broad anti-fungal activity.

Authors:  Nuo Sun; Dongmei Li; Yuhan Zhang; Kyle Killeen; William Groutas; Richard Calderone
Journal:  Sci Rep       Date:  2017-12-05       Impact factor: 4.379

5.  Potential of Gallium as an Antifungal Agent.

Authors:  Rafael Wesley Bastos; Luana Rossato; Clara Valero; Katrien Lagrou; Arnaldo Lopes Colombo; Gustavo H Goldman
Journal:  Front Cell Infect Microbiol       Date:  2019-12-11       Impact factor: 5.293

6.  Antimicrobial Activity of Gallium Compounds on ESKAPE Pathogens.

Authors:  Sarah Hijazi; Daniela Visaggio; Mattia Pirolo; Emanuela Frangipani; Lawrence Bernstein; Paolo Visca
Journal:  Front Cell Infect Microbiol       Date:  2018-09-10       Impact factor: 5.293

  6 in total

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