Literature DB >> 20014826

Total solid-phase synthesis of NOTA-functionalized peptides for PET imaging.

Brigitte Guérin1, Samia Ait-Mohand, Marie-Claude Tremblay, Véronique Dumulon-Perreault, Patrick Fournier, François Bénard.   

Abstract

A convenient approach to functionalize peptides either at the N-terminal or on a lysine side chain with 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) chelating unit has been developed on solid support. The chelate was assembled in a two-step process starting with bromo-acetylated peptides. Deprotection and cleavage of the resin-bound NOTA peptides were performed with use of trifluoroacetic acid (TFA) in the presence of thioanisole and water to give free NOTA peptides.

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Year:  2010        PMID： 20014826     DOI： 10.1021/ol902601x

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

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6.  PACE4-based molecular targeting of prostate cancer using an engineered ⁶⁴Cu-radiolabeled peptide inhibitor.

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7.  Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker.

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8.  A convenient and efficient total solid-phase synthesis of DOTA-functionalized tumor-targeting peptides for PET imaging of cancer.

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  8 in total

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