Literature DB >> 20014447

Integrative molecular characterization of head and neck cancer cell model genomes.

Ivy F L Tsui1, Cathie Garnis.   

Abstract

BACKGROUND: Cell lines are invaluable model systems for the investigation of cancer. Knowledge of the molecular alterations that exist within cell models is required to define the mechanisms governing cellular phenotypes.
METHODS: Five tongue squamous cell carcinomas cell lines and 1 submaxillary salivary gland epidermoid carcinoma cell line were analyzed for copy number and mRNA expression by tiling-path DNA microarrays and Agilent Whole Human Genome Oligoarrays, respectively.
RESULTS: Integrative analysis of genetic and expression alterations revealed the molecular landscape of each cell line. Molecular results for individual cell lines and across all samples have been summarized and made available for easy reference.
CONCLUSION: Our integrative genomic analyses have defined the DNA and RNA alterations for each individual line. These data will be useful to anyone modeling oral cancer behavior, providing a molecular context that will be useful for deciphering cell phenotypes.

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Year:  2010        PMID： 20014447      PMCID： PMC2930055          DOI： 10.1002/hed.21311

Source DB:  PubMed          Journal:  Head Neck        ISSN： 1043-3074            Impact factor:   3.147


  31 in total

1.  Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.

Authors:  M P Rosin; X Cheng; C Poh; W L Lam; Y Huang; J Lovas; K Berean; J B Epstein; R Priddy; N D Le; L Zhang
Journal:  Clin Cancer Res       Date:  2000-02       Impact factor: 12.531

Review 2.  Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.

Authors:  Charles J Lin; Jennifer R Grandis; Thomas E Carey; Susanne M Gollin; Theresa L Whiteside; Wayne M Koch; Robert L Ferris; Stephen Y Lai
Journal:  Head Neck       Date:  2007-02       Impact factor: 3.147

3.  Cancer: drivers and passengers.

Authors:  Daniel A Haber; Jeff Settleman
Journal:  Nature       Date:  2007-03-08       Impact factor: 49.962

4.  High frequency of homozygous deletion and methylation of p16(INK4A) gene in oral squamous cell carcinomas.

Authors:  Y Nakahara; S Shintani; M Mihara; Y Ueyama; T Matsumura
Journal:  Cancer Lett       Date:  2001-02-26       Impact factor: 8.679

5.  Multiple aberrations of chromosome 3p detected in oral premalignant lesions.

Authors:  Ivy F L Tsui; Miriam P Rosin; Lewei Zhang; Raymond T Ng; Wan L Lam
Journal:  Cancer Prev Res (Phila)       Date:  2008-11

Review 6.  Molecular pathogenesis of head and neck cancers.

Authors:  Bhuvanesh Singh
Journal:  J Surg Oncol       Date:  2008-06-15       Impact factor: 3.454

Review 7.  Chromosomal imbalances in oral squamous cell carcinoma: examination of 31 cell lines and review of the literature.

Authors:  Christa Lese Martin; Shalini C Reshmi; Thomas Ried; William Gottberg; John W Wilson; Jaya K Reddy; Poornima Khanna; Jonas T Johnson; Eugene N Myers; Susanne M Gollin
Journal:  Oral Oncol       Date:  2007-08-02       Impact factor: 5.337

8.  High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx.

Authors:  Anna-Kaarina Järvinen; Reija Autio; Sami Kilpinen; Matti Saarela; Ilmo Leivo; Reidar Grénman; Antti A Mäkitie; Outi Monni
Journal:  Genes Chromosomes Cancer       Date:  2008-06       Impact factor: 5.006

9.  DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers.

Authors:  W W Lockwood; R Chari; B P Coe; L Girard; C Macaulay; S Lam; A F Gazdar; J D Minna; W L Lam
Journal:  Oncogene       Date:  2008-04-07       Impact factor: 9.867

10.  MD-SeeGH: a platform for integrative analysis of multi-dimensional genomic data.

Authors:  Bryan Chi; Ronald J deLeeuw; Bradley P Coe; Raymond T Ng; Calum MacAulay; Wan L Lam
Journal:  BMC Bioinformatics       Date:  2008-05-20       Impact factor: 3.169
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  7 in total

1.  Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions.

Authors:  Rebecca Towle; Ivy F L Tsui; Yuqi Zhu; Sara MacLellan; Catherine F Poh; Cathie Garnis
Journal:  Cancer Med       Date:  2014-07-24       Impact factor: 4.452

2.  A Robust Protocol for Using Multiplexed Droplet Digital PCR to Quantify Somatic Copy Number Alterations in Clinical Tissue Specimens.

Authors:  Curtis B Hughesman; X J David Lu; Kelly Y P Liu; Yuqi Zhu; Catherine F Poh; Charles Haynes
Journal:  PLoS One       Date:  2016-08-18       Impact factor: 3.240

3.  Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes.

Authors:  Christopher T D Dickman; James Lawson; James Jabalee; Sara A MacLellan; Nancy E LePard; Kevin L Bennewith; Cathie Garnis
Journal:  Oncotarget       Date:  2017-02-28

4.  The EGFR Inhibitor Gefitinib Enhanced the Response of Human Oral Squamous Cell Carcinoma to Cisplatin In Vitro.

Authors:  Ashraf Khalil; Mark J Jameson
Journal:  Drugs R D       Date:  2017-12

5.  Detection of clinically relevant copy number alterations in oral cancer progression using multiplexed droplet digital PCR.

Authors:  Curtis B Hughesman; X J David Lu; Kelly Y P Liu; Yuqi Zhu; Rebecca M Towle; Charles Haynes; Catherine F Poh
Journal:  Sci Rep       Date:  2017-09-19       Impact factor: 4.379

6.  Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9.

Authors:  Vui King Vincent-Chong; Arif Anwar; Lee Peng Karen-Ng; Sok Ching Cheong; Yi-Hsin Yang; Padmaja Jayaprasad Pradeep; Zainal Ariff Abdul Rahman; Siti Mazlipah Ismail; Zuraiza Mohamad Zaini; Narayanan Prepageran; Thomas George Kallarakkal; Anand Ramanathan; Nur Aaina Binti Mohd Mohayadi; Nurul Shielawati Binti Mohamed Rosli; Wan Mahadzir Wan Mustafa; Mannil Thomas Abraham; Keng Kiong Tay; Rosnah Binti Zain
Journal:  PLoS One       Date:  2013-02-06       Impact factor: 3.240

7.  Interpreting pathways to discover cancer driver genes with Moonlight.

Authors:  Antonio Colaprico; Catharina Olsen; Matthew H Bailey; Gabriel J Odom; Thilde Terkelsen; Tiago C Silva; André V Olsen; Laura Cantini; Andrei Zinovyev; Emmanuel Barillot; Houtan Noushmehr; Gloria Bertoli; Isabella Castiglioni; Claudia Cava; Gianluca Bontempi; Xi Steven Chen; Elena Papaleo
Journal:  Nat Commun       Date:  2020-01-03       Impact factor: 14.919
  7 in total

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