OBJECTIVE: The aim of this study was to compare cystatin C versus creatinine as a marker for acute kidney injury in patients submitted to cardiac surgery with cardiopulmonary bypass. METHODS: Fifty consecutive patients submitted to coronary artery bypass grafting were studied. Renal function was evaluated by serum cystatin C and creatinine. Blood samples were obtained from each patient at three time points: before operation, and on the first and fifth postoperative days. Glomerular filtration rate (GFR) was calculated by Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Larsson (Cys-GFR) formulas. RESULTS: Creatinine and GFR by CG and MDRD formulas did not show statistical difference between study times. After renal injury from surgery, there was an increase in cystatin C on the 1st and 5th day after surgery, being significantly different on the 5th postoperative (P<0.01). The GFR by Larson formula was higher in the preoperative time (105.2 +/- 41.0 ml/min) than in the 5th postoperative day (89.5+/- 31.5 ml/min; P<0.012). CONCLUSION: The cystatin C and the Cys-GFR showed significant changes after cardiac surgery when compared with the creatinine and respective GFR calculated by the Cockcroft-Gault and MDRD formulas.
OBJECTIVE: The aim of this study was to compare cystatin C versus creatinine as a marker for acute kidney injury in patients submitted to cardiac surgery with cardiopulmonary bypass. METHODS: Fifty consecutive patients submitted to coronary artery bypass grafting were studied. Renal function was evaluated by serum cystatin C and creatinine. Blood samples were obtained from each patient at three time points: before operation, and on the first and fifth postoperative days. Glomerular filtration rate (GFR) was calculated by Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and Larsson (Cys-GFR) formulas. RESULTS:Creatinine and GFR by CG and MDRD formulas did not show statistical difference between study times. After renal injury from surgery, there was an increase in cystatin C on the 1st and 5th day after surgery, being significantly different on the 5th postoperative (P<0.01). The GFR by Larson formula was higher in the preoperative time (105.2 +/- 41.0 ml/min) than in the 5th postoperative day (89.5+/- 31.5 ml/min; P<0.012). CONCLUSION: The cystatin C and the Cys-GFR showed significant changes after cardiac surgery when compared with the creatinine and respective GFR calculated by the Cockcroft-Gault and MDRD formulas.
Authors: Anders S Svensson; Csaba P Kovesdy; John-Peder Escobar Kvitting; Magnus Rosén; Ingemar Cederholm; Zoltán Szabó Journal: Int Urol Nephrol Date: 2013-03-06 Impact factor: 2.370
Authors: Wolfgang Buhre; Dianne de Korte-de Boer; Marcelo Gama de Abreu; Thomas Scheeren; Matthias Gruenewald; Andreas Hoeft; Donat R Spahn; Alexander Zarbock; Sylvia Daamen; Martin Westphal; Ute Brauer; Tamara Dehnhardt; Sonja Schmier; Jean-Francois Baron; Stefan De Hert; Željka Gavranović; Bernard Cholley; Tomas Vymazal; Wojciech Szczeklik; Helmar Bornemann-Cimenti; Marina Blanca Soro Domingo; Ioana Grintescu; Radmilo Jankovic; Javier Belda Journal: Trials Date: 2022-02-22 Impact factor: 2.279