Literature DB >> 2001174

The plus strand is discontinuous in a subpopulation of unintegrated HIV-1 DNA.

O Hungnes1, E Tjotta, B Grinde.   

Abstract

During reverse transcription the synthesis of plus strand viral DNA is initiated from an RNA polypurine primer immediately upstream of the U 3 region. The polypurine tract (PPT) sequence at this site is in HIV-1 also present in the middle of the genome. Here we demonstrate that a subpopulation of linear unintegrated HIV-1 DNA has a discontinuity in the plus strand within less than 50 bp from this central PPT, consistent with its utilization as a plus strand initiation site.

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Year:  1991        PMID： 2001174     DOI： 10.1007/bf01319237

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  20 in total

1.  Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus.

Authors:  P Sonigo; M Alizon; K Staskus; D Klatzmann; S Cole; O Danos; E Retzel; P Tiollais; A Haase; S Wain-Hobson
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

2.  Evidence for a gapped linear duplex DNA intermediate in the replicative cycle of human and simian spumaviruses.

Authors:  J J Kupiec; J Tobaly-Tapiero; M Canivet; M Santillana-Hayat; R M Flügel; J Périès; R Emanoil-Ravier
Journal:  Nucleic Acids Res       Date:  1988-10-25       Impact factor: 16.971

3.  Nucleotide sequence of the AIDS virus, LAV.

Authors:  S Wain-Hobson; P Sonigo; O Danos; S Cole; M Alizon
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

4.  Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus.

Authors:  M A Muesing; D H Smith; C D Cabradilla; C V Benton; L A Lasky; D J Capon
Journal:  Nature       Date:  1985 Feb 7-13       Impact factor: 49.962

5.  Evidence for involvement of an RNA primer in initiation of strong-stop plus DNA synthesis during reverse transcription in vitro.

Authors:  C A Omer; R Resnick; A J Faras
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

6.  Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeat.

Authors:  R Resnick; C A Omer; A J Faras
Journal:  J Virol       Date:  1984-09       Impact factor: 5.103

7.  Visna virus DNA: discovery of a novel gapped structure.

Authors:  J D Harris; J V Scott; B Traynor; M Brahic; L Stowring; P Ventura; A T Haase; R Peluso
Journal:  Virology       Date:  1981-09       Impact factor: 3.616

8.  Discontinuities in the DNA synthesized by an avian retrovirus.

Authors:  J M Taylor; A Cywinski; J K Smith
Journal:  J Virol       Date:  1983-12       Impact factor: 5.103

9.  Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses.

Authors:  G Franchini; C Gurgo; H G Guo; R C Gallo; E Collalti; K A Fargnoli; L F Hall; F Wong-Staal; M S Reitz
Journal:  Nature       Date:  1987 Aug 6-12       Impact factor: 49.962

10.  Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses.

Authors:  L Chakrabarti; M Guyader; M Alizon; M D Daniel; R C Desrosiers; P Tiollais; P Sonigo
Journal:  Nature       Date:  1987 Aug 6-12       Impact factor: 49.962
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  18 in total

1.  Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector.

Authors:  Boris Kantor; Matthew Bayer; Hong Ma; Jude Samulski; Chengwen Li; Thomas McCown; Tal Kafri
Journal:  Mol Ther       Date:  2010-12-14       Impact factor: 11.454

2.  Functional central polypurine tract provides downstream protection of the human immunodeficiency virus type 1 genome from editing by APOBEC3G and APOBEC3B.

Authors:  Sebastien Wurtzer; Armelle Goubard; Fabrizio Mammano; Sentob Saragosti; Denise Lecossier; Allan J Hance; François Clavel
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

3.  Posttranscriptional modification of retroviral primers is required for late stages of DNA replication.

Authors:  B P Burnett; C S McHenry
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

4.  Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap.

Authors:  Ana Limón; Noriko Nakajima; Richard Lu; Hina Z Ghory; Alan Engelman
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

Review 5.  Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise.

Authors:  Stuart F J Le Grice
Journal:  J Biol Chem       Date:  2012-10-05       Impact factor: 5.157

6.  Human immunodeficiency virus type 1 central DNA flap: dynamic terminal product of plus-strand displacement dna synthesis catalyzed by reverse transcriptase assisted by nucleocapsid protein.

Authors:  L Hameau; J Jeusset; S Lafosse; D Coulaud; E Delain; T Unge; T Restle; E Le Cam; G Mirambeau
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

7.  Partial rescue of the Vif-negative phenotype of mutant human immunodeficiency virus type 1 strains from nonpermissive cells by intravirion reverse transcription.

Authors:  G Dornadula; S Yang; R J Pomerantz; H Zhang
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

8.  Efficient initiation and strand transfer of polypurine tract-primed plus-strand DNA prevent strand transfer of internally initiated plus-strand DNA.

Authors:  E H Bowman; V K Pathak; W S Hu
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

9.  Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free system.

Authors:  G J Klarmann; H Yu; X Chen; J P Dougherty; B D Preston
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

10.  Identification and characterization of an exogenous retrovirus from atlantic salmon swim bladder sarcomas.

Authors:  Thomas A Paul; Sandra L Quackenbush; Claudia Sutton; Rufina N Casey; Paul R Bowser; James W Casey
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103
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