| Literature DB >> 20011581 |
Francisco J Sayago1, M Isabel Calaza, Ana I Jiménez, Carlos Cativiela.
Abstract
A high yielding and remarkably stereoselective alpha-methylation reaction of the (2S,3aS,7aS) stereoisomer of octahydroindole-2-carboxylic acid, (S,S,S)-Oic, suitably protected is described. The severe steric hindrance imposed by the fused cyclohexane ring, which prevents the application of Seebach's self-reproduction of chirality methodology, accounts for the formation of (S,S,S)-(alphaMe)Oic with high selectivity and retention of configuration.Entities:
Year: 2008 PMID： 20011581 PMCID： PMC2711560 DOI： 10.1016/j.tetasy.2008.11.030
Source DB: PubMed Journal: Tetrahedron Asymmetry ISSN： 0957-4166