Literature DB >> 2001104

Depot testosterone in boys with anorchia or gonadotrophin deficiency: effect on growth rate and adult height.

B Moorthy1, M Papadopolou, D G Shaw, D B Grant.   

Abstract

Eleven teenage boys with bilateral anorchia and 12 with gonadotrophin deficiency were treated by injections of testosterone ester (enanthate) at an initial dose of 100 mg every six to eight weeks, rising to 250 mg every four weeks after three to four years. In the anorchic boys average adult height was 177.1 cm, compared with a mean mid-parental height of 174.4 cm, and mean predicted adult heights of 177.0 cm (Tanner-Whitehouse method) and 178.0 cm (Bayley-Pinneau method). In the patients with gonadotrophin deficiency, mean adult height was 176.9 cm, compared with a mean mid-parental height of 176.1 cm, and mean predicted adults heights of 174.0 cm (Tanner-Whitehouse method) and 177.3 cm (Bayley-Pinneau method). We conclude that this testosterone regimen allows achievement of full growth potential in such patients.

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Year:  1991        PMID: 2001104      PMCID: PMC1792824          DOI: 10.1136/adc.66.2.197

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN: 0003-9888            Impact factor:   3.791


  11 in total

1.  Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards.

Authors:  N BAYLEY; S R PINNEAU
Journal:  J Pediatr       Date:  1952-04       Impact factor: 4.406

2.  Oxandrolone treatment of constitutional short stature in boys during adolescence: effect on linear growth, bone age, pubic hair, and testicular development.

Authors:  C Marti-Henneberg; A K Niirianen; R Rappaport
Journal:  J Pediatr       Date:  1975-05       Impact factor: 4.406

3.  Effects of testosterone therapy for pubertal delay.

Authors:  D M Wilson; J Kei; R L Hintz; R G Rosenfeld
Journal:  Am J Dis Child       Date:  1988-01

4.  Prediction of adult height with various methods in Finnish children.

Authors:  H L Lenko
Journal:  Acta Paediatr Scand       Date:  1979-01

5.  Diagnostic value of testosterone therapy in boys with delayed puberty.

Authors:  P B Kaplowitz
Journal:  Am J Dis Child       Date:  1989-01

6.  Short stature and pubertal delay in male adolescents with cystic fibrosis. Androgen treatment.

Authors:  C Landon; R G Rosenfeld
Journal:  Am J Dis Child       Date:  1984-04

7.  A prospective, randomized study of testosterone treatment of constitutional delay of growth and development in male adolescents.

Authors:  R G Rosenfeld; G B Northcraft; R L Hintz
Journal:  Pediatrics       Date:  1982-06       Impact factor: 7.124

8.  Congenital bilateral anorchia in childhood: a clinical, endocrine and therapeutic evaluation of twenty-one cases.

Authors:  A Aynsley-Green; M Zachmann; R Illig; S Rampini; A Prader
Journal:  Clin Endocrinol (Oxf)       Date:  1976-07       Impact factor: 3.478

9.  Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism.

Authors:  A Aynsley-Green; M Zachmann; A Prader
Journal:  J Pediatr       Date:  1976-12       Impact factor: 4.406

10.  Anabolic and androgenic effect of testosterone in sexually immature boys and its dependency on growth hormone.

Authors:  M Zachmann; A Prader
Journal:  J Clin Endocrinol Metab       Date:  1970-01       Impact factor: 6.134

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  3 in total

1.  Childhood growth in boys with congenital hypogonadotropic hypogonadism.

Authors:  Tero Varimo; Matti Hero; Eeva-Maria Laitinen; Päivi J Miettinen; Johanna Tommiska; Johanna Känsäkoski; Anders Juul; Taneli Raivio
Journal:  Pediatr Res       Date:  2015-12-31       Impact factor: 3.756

2.  Altered ghrelin levels in boys with autism: a novel finding associated with hormonal dysregulation.

Authors:  Felwah S Al-Zaid; AbdelFattah A Alhader; Laila Y Al-Ayadhi
Journal:  Sci Rep       Date:  2014-09-26       Impact factor: 4.379

3.  Observational study of clinical outcomes for testosterone treatment of pubertal delay in Duchenne muscular dystrophy.

Authors:  C L Wood; T D Cheetham; K G Hollingsworth; M Guglieri; Y Ailins-Sahun; S Punniyakodi; A Mayhew; V Straub
Journal:  BMC Pediatr       Date:  2019-04-25       Impact factor: 2.125

  3 in total

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