Literature DB >> 20010832

A reprogrammable mouse strain from gene-targeted embryonic stem cells.

Matthias Stadtfeld1, Nimet Maherali, Marti Borkent, Konrad Hochedlinger.   

Abstract

The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming.

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Year:  2009        PMID： 20010832      PMCID： PMC3987893          DOI： 10.1038/nmeth.1409

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  15 in total

1.  Dissecting direct reprogramming through integrative genomic analysis.

Authors:  Tarjei S Mikkelsen; Jacob Hanna; Xiaolan Zhang; Manching Ku; Marius Wernig; Patrick Schorderet; Bradley E Bernstein; Rudolf Jaenisch; Eric S Lander; Alexander Meissner
Journal:  Nature       Date:  2008-05-28       Impact factor: 49.962

2.  Generation of induced pluripotent stem cells in the absence of drug selection.

Authors:  Robert Blelloch; Monica Venere; Jonathan Yen; Miguel Ramalho-Santos
Journal:  Cell Stem Cell       Date:  2007-09-06       Impact factor: 24.633

3.  Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.

Authors:  Matthias Stadtfeld; Nimet Maherali; David T Breault; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2008-02-14       Impact factor: 24.633

4.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

5.  Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells.

Authors:  Caroline Beard; Konrad Hochedlinger; Kathrin Plath; Anton Wutz; Rudolf Jaenisch
Journal:  Genesis       Date:  2006-01       Impact factor: 2.487

6.  Oct4 expression is not required for mouse somatic stem cell self-renewal.

Authors:  Christopher J Lengner; Fernando D Camargo; Konrad Hochedlinger; G Grant Welstead; Samir Zaidi; Sumita Gokhale; Hans R Scholer; Alexey Tomilin; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2007-10-11       Impact factor: 24.633

7.  A high-efficiency system for the generation and study of human induced pluripotent stem cells.

Authors:  Nimet Maherali; Tim Ahfeldt; Alessandra Rigamonti; Jochen Utikal; Chad Cowan; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2008-09-11       Impact factor: 24.633

8.  A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.

Authors:  Marius Wernig; Christopher J Lengner; Jacob Hanna; Michael A Lodato; Eveline Steine; Ruth Foreman; Judith Staerk; Styliani Markoulaki; Rudolf Jaenisch
Journal:  Nat Biotechnol       Date:  2008-07-01       Impact factor: 54.908

9.  Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells.

Authors:  Tobias Brambrink; Ruth Foreman; G Grant Welstead; Christopher J Lengner; Marius Wernig; Heikyung Suh; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2008-02-07       Impact factor: 24.633

10.  Role of the murine reprogramming factors in the induction of pluripotency.

Authors:  Rupa Sridharan; Jason Tchieu; Mike J Mason; Robin Yachechko; Edward Kuoy; Steve Horvath; Qing Zhou; Kathrin Plath
Journal:  Cell       Date:  2009-01-23       Impact factor: 41.582
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  100 in total

1.  Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4.

Authors:  A Nemajerova; S Y Kim; O Petrenko; U M Moll
Journal:  Cell Death Differ       Date:  2012-04-27       Impact factor: 15.828

Review 2.  Induced pluripotency: history, mechanisms, and applications.

Authors:  Matthias Stadtfeld; Konrad Hochedlinger
Journal:  Genes Dev       Date:  2010-10-15       Impact factor: 11.361

3.  Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells.

Authors:  Jose M Polo; Susanna Liu; Maria Eugenia Figueroa; Warakorn Kulalert; Sarah Eminli; Kah Yong Tan; Effie Apostolou; Matthias Stadtfeld; Yushan Li; Toshi Shioda; Sridaran Natesan; Amy J Wagers; Ari Melnick; Todd Evans; Konrad Hochedlinger
Journal:  Nat Biotechnol       Date:  2010-07-19       Impact factor: 54.908

4.  Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain.

Authors:  Hiroyuki Hirai; Nobuko Katoku-Kikyo; Susan A Keirstead; Nobuaki Kikyo
Journal:  Cardiovasc Res       Date:  2013-06-20       Impact factor: 10.787

Review 5.  Toward pluripotency by reprogramming: mechanisms and application.

Authors:  Tao Wang; Stephen T Warren; Peng Jin
Journal:  Protein Cell       Date:  2013-11       Impact factor: 14.870

6.  Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

Authors:  María Abad; Lluc Mosteiro; Cristina Pantoja; Marta Cañamero; Teresa Rayon; Inmaculada Ors; Osvaldo Graña; Diego Megías; Orlando Domínguez; Dolores Martínez; Miguel Manzanares; Sagrario Ortega; Manuel Serrano
Journal:  Nature       Date:  2013-09-11       Impact factor: 49.962

7.  Generation of a drug-inducible reporter system to study cell reprogramming in human cells.

Authors:  Sergio Ruiz; Athanasia D Panopoulos; Nuria Montserrat; Marie-Christine Multon; Aurélie Daury; Corinne Rocher; Emmanuel Spanakis; Erika M Batchelder; Cécile Orsini; Jean-François Deleuze; Juan Carlos Izpisua Belmonte
Journal:  J Biol Chem       Date:  2012-09-27       Impact factor: 5.157

Review 8.  Mechanisms underlying the formation of induced pluripotent stem cells.

Authors:  Federico González; Danwei Huangfu
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2015-09-18       Impact factor: 5.814

9.  Remote control of induced dopaminergic neurons in parkinsonian rats.

Authors:  Maria Teresa Dell'Anno; Massimiliano Caiazzo; Damiana Leo; Elena Dvoretskova; Lucian Medrihan; Gaia Colasante; Serena Giannelli; Ilda Theka; Giovanni Russo; Liudmila Mus; Gianni Pezzoli; Raul R Gainetdinov; Fabio Benfenati; Stefano Taverna; Alexander Dityatev; Vania Broccoli
Journal:  J Clin Invest       Date:  2014-06-17       Impact factor: 14.808

10.  KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks.

Authors:  Dafne Campigli Di Giammartino; Andreas Kloetgen; Alexander Polyzos; Yiyuan Liu; Daleum Kim; Dylan Murphy; Abderhman Abuhashem; Paola Cavaliere; Boaz Aronson; Veevek Shah; Noah Dephoure; Matthias Stadtfeld; Aristotelis Tsirigos; Effie Apostolou
Journal:  Nat Cell Biol       Date:  2019-09-23       Impact factor: 28.824
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