Literature DB >> 20010831

Single-gene transgenic mouse strains for reprogramming adult somatic cells.

Bryce W Carey1, Styliani Markoulaki, Caroline Beard, Jacob Hanna, Rudolf Jaenisch.   

Abstract

We report transgenic mouse models in which three or four reprogramming factors are expressed from a single genomic locus using a drug-inducible transgene. Multiple somatic cell types can be directly reprogrammed to generate induced pluripotent stem cells (iPSCs) by culture in doxycycline. Because reprogramming factors are carried on a single polycistronic construct, the mice can be easily maintained, and the transgene can be easily transferred into other genetic backgrounds.

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Year:  2009        PMID： 20010831      PMCID： PMC3048025          DOI： 10.1038/nmeth.1410

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  15 in total

1.  Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Authors:  Frank Soldner; Dirk Hockemeyer; Caroline Beard; Qing Gao; George W Bell; Elizabeth G Cook; Gunnar Hargus; Alexandra Blak; Oliver Cooper; Maisam Mitalipova; Ole Isacson; Rudolf Jaenisch
Journal:  Cell       Date:  2009-03-06       Impact factor: 41.582

2.  Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Authors:  Nimet Maherali; Rupa Sridharan; Wei Xie; Jochen Utikal; Sarah Eminli; Katrin Arnold; Matthias Stadtfeld; Robin Yachechko; Jason Tchieu; Rudolf Jaenisch; Kathrin Plath; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

3.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

4.  A drug-inducible system for direct reprogramming of human somatic cells to pluripotency.

Authors:  Dirk Hockemeyer; Frank Soldner; Elizabeth G Cook; Qing Gao; Maisam Mitalipova; Rudolf Jaenisch
Journal:  Cell Stem Cell       Date:  2008-09-11       Impact factor: 24.633

5.  A high-efficiency system for the generation and study of human induced pluripotent stem cells.

Authors:  Nimet Maherali; Tim Ahfeldt; Alessandra Rigamonti; Jochen Utikal; Chad Cowan; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2008-09-11       Impact factor: 24.633

6.  Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.

Authors:  Jacob Hanna; Styliani Markoulaki; Patrick Schorderet; Bryce W Carey; Caroline Beard; Marius Wernig; Menno P Creyghton; Eveline J Steine; John P Cassady; Ruth Foreman; Christopher J Lengner; Jessica A Dausman; Rudolf Jaenisch
Journal:  Cell       Date:  2008-04-18       Impact factor: 41.582

7.  A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.

Authors:  Marius Wernig; Christopher J Lengner; Jacob Hanna; Michael A Lodato; Eveline Steine; Ruth Foreman; Judith Staerk; Styliani Markoulaki; Rudolf Jaenisch
Journal:  Nat Biotechnol       Date:  2008-07-01       Impact factor: 54.908

8.  Reprogramming of murine and human somatic cells using a single polycistronic vector.

Authors:  Bryce W Carey; Styliani Markoulaki; Jacob Hanna; Kris Saha; Qing Gao; Maisam Mitalipova; Rudolf Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-24       Impact factor: 11.205

9.  In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Authors:  Marius Wernig; Alexander Meissner; Ruth Foreman; Tobias Brambrink; Manching Ku; Konrad Hochedlinger; Bradley E Bernstein; Rudolf Jaenisch
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

10.  Transgenic mice with defined combinations of drug-inducible reprogramming factors.

Authors:  Styliani Markoulaki; Jacob Hanna; Caroline Beard; Bryce W Carey; Albert W Cheng; Christopher J Lengner; Jessica A Dausman; Dongdong Fu; Qing Gao; Su Wu; John P Cassady; Rudolf Jaenisch
Journal:  Nat Biotechnol       Date:  2009-01-18       Impact factor: 54.908
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  94 in total

1.  Two-factor reprogramming of somatic cells to pluripotent stem cells reveals partial functional redundancy of Sox2 and Klf4.

Authors:  A Nemajerova; S Y Kim; O Petrenko; U M Moll
Journal:  Cell Death Differ       Date:  2012-04-27       Impact factor: 15.828

Review 2.  Induced pluripotency: history, mechanisms, and applications.

Authors:  Matthias Stadtfeld; Konrad Hochedlinger
Journal:  Genes Dev       Date:  2010-10-15       Impact factor: 11.361

3.  Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

Authors:  María Abad; Lluc Mosteiro; Cristina Pantoja; Marta Cañamero; Teresa Rayon; Inmaculada Ors; Osvaldo Graña; Diego Megías; Orlando Domínguez; Dolores Martínez; Miguel Manzanares; Sagrario Ortega; Manuel Serrano
Journal:  Nature       Date:  2013-09-11       Impact factor: 49.962

4.  Reduce, reuse, reprogram.

Authors:  Thomas P Zwaka
Journal:  Nat Methods       Date:  2010-01       Impact factor: 28.547

5.  Stem Cell Surface Marker Expression Defines Late Stages of Reprogramming to Pluripotency in Human Fibroblasts.

Authors:  Jordan E Pomeroy; Shelley R Hough; Kathryn C Davidson; Alex M Quaas; Jordan A Rees; Martin F Pera
Journal:  Stem Cells Transl Med       Date:  2016-05-09       Impact factor: 6.940

Review 6.  Progress in understanding reprogramming to the induced pluripotent state.

Authors:  Kathrin Plath; William E Lowry
Journal:  Nat Rev Genet       Date:  2011-04       Impact factor: 53.242

7.  Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming.

Authors:  Yasong Wu; Yuan Li; Hui Zhang; Yinghua Huang; Ping Zhao; Yujia Tang; Xiaohui Qiu; Yue Ying; Wen Li; Su Ni; Meng Zhang; Longqi Liu; Yan Xu; Qiang Zhuang; Zhiwei Luo; Christina Benda; Hong Song; Baohua Liu; Liangxue Lai; Xingguo Liu; Hung-Fat Tse; Xichen Bao; Wai-Yee Chan; Miguel A Esteban; Baoming Qin; Duanqing Pei
Journal:  Nat Cell Biol       Date:  2015-05-18       Impact factor: 28.824

8.  Cell type-specific expression profile and signaling requirements in early hematopoietic reprogramming.

Authors:  Lan Kang; Jun Wu; Yu Tao; Haolan Li; Xiaolei Liu; Shaorong Gao; Qian-Fei Wang
Journal:  Stem Cells Dev       Date:  2015-04-06       Impact factor: 3.272

Review 9.  Mechanisms underlying the formation of induced pluripotent stem cells.

Authors:  Federico González; Danwei Huangfu
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2015-09-18       Impact factor: 5.814

10.  Selection via pluripotency-related transcriptional screen minimizes the influence of somatic origin on iPSC differentiation propensity.

Authors:  Katherine A Hartjes; Xing Li; Almudena Martinez-Fernandez; Alexa J Roemmich; Brandon T Larsen; Andre Terzic; Timothy J Nelson
Journal:  Stem Cells       Date:  2014-09       Impact factor: 6.277
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