| Literature DB >> 20010824 |
Arko Ghosh1, Florent Haiss, Esther Sydekum, Regula Schneider, Miriam Gullo, Matthias T Wyss, Thomas Mueggler, Christof Baltes, Markus Rudin, Bruno Weber, Martin E Schwab.
Abstract
Little is known about the functional role of axotomized cortical neurons that survive spinal cord injury. Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function. Using retrograde tracers, we found that axotomized corticospinal axons from the hindlimb sensorimotor cortex sprouted in the cervical spinal cord. Mapping of these neurons revealed the emergence of a new forelimb corticospinal projection from the rostral part of the former hindlimb cortex. Voltage-sensitive dye (VSD) imaging and blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) revealed a stable expansion of the forelimb sensory map, covering in particular the former hindlimb cortex containing the rewired neurons. Therefore, axotomized hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb.Entities:
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Year: 2009 PMID： 20010824 DOI： 10.1038/nn.2448
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884